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Ferdinand M. van't Hooft

Researcher at Karolinska Institutet

Publications -  24
Citations -  5327

Ferdinand M. van't Hooft is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 18, co-authored 24 publications receiving 5133 citations. Previous affiliations of Ferdinand M. van't Hooft include Karolinska University Hospital & Leiden University.

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Genetic studies of body mass index yield new insights for obesity biology

Adam E. Locke, +481 more
TL;DR: This paper conducted a genome-wide association study and meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals.
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A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

John F. Peden, +110 more
- 01 Apr 2011 - 
TL;DR: Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD), a modest number considering the apparent heritability of CAD(8) as mentioned in this paper.
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A Common Functional Polymorphism (C→A Substitution at Position −863) in the Promoter Region of the Tumour Necrosis Factor-α (TNF-α) Gene Associated With Reduced Circulating Levels of TNF-α

TL;DR: The characterization of a common functional polymorphism in the promoter region of the TNF-alpha gene, a C-->A substitution at position -863, is reported, which is functional in vitro in monocytic and hepatic cells and influences the serum T NF-alpha concentration in vivo in healthy middle-aged men.
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TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

TL;DR: Transmembrane 6 superfamily member 2 (TM6SF2), a gene with hitherto unknown function, expressed predominantly in liver and intestine, was identified as the putative causal gene and is concluded to be a novel regulator of liver fat metabolism with opposing effects on the secretion of TRLs and hepatic TG content.
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Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease

Adam S. Butterworth, +355 more
TL;DR: This large-scale gene-centric analysis has identified several novel genes for CAD that relate to diverse biochemical and cellular functions and clarified the literature with regard to many previously suggested genes.