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Abdus Samad
Researcher at Karachi Institute of Heart Diseases
Publications - 13
Citations - 1151
Abdus Samad is an academic researcher from Karachi Institute of Heart Diseases. The author has contributed to research in topics: Myocardial perfusion imaging & Population. The author has an hindex of 7, co-authored 13 publications receiving 1062 citations.
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Journal ArticleDOI
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
John F. Peden,Jemma C. Hopewell,Danish Saleheen,John C. Chambers,Jorg Hager,Nicole Soranzo,Rory Collins,John Danesh,Paul Elliott,Martin Farrall,Kathy Stirrups,Weihua Zhang,Anders Hamsten,Anders Hamsten,Sarah Parish,Mark Lathrop,Hugh Watkins,Robert Clarke,Panos Deloukas,Jaspal S. Kooner,Anuj Goel,Halit Ongen,Rona J. Strawbridge,Rona J. Strawbridge,Simon Heath,Anders Mälarstig,Anders Mälarstig,Anna Helgadottir,John Öhrvik,John Öhrvik,Muhammed Murtaza,Simon C. Potter,Sarah E. Hunt,Marc Delepine,Shapour Jalilzadeh,Tomas Axelsson,Ann-Christine Syvänen,Rhian Gwilliam,Suzannah Bumpstead,Emma Gray,Sarah Edkins,Lasse Folkersen,Lasse Folkersen,Theodosios Kyriakou,Anders Franco-Cereceda,Anders Gabrielsen,Udo Seedorf,Per Eriksson,Per Eriksson,Alison Offer,Louise Bowman,Peter Sleight,Jane Armitage,Richard Peto,Gonçalo R. Abecasis,Nabeel Ahmed,Mark J. Caulfield,Peter Donnelly,Philippe Froguel,Angad S. Kooner,Mark I. McCarthy,Nilesh J. Samani,James Scott,Joban Sehmi,Angela Silveira,Angela Silveira,Mai-Lis Hellénius,Ferdinand M. van't Hooft,Ferdinand M. van't Hooft,Gunnar O Olsson,Stephan Rust,Gerd Assmann,Simona Barlera,Gianni Tognoni,Maria Grazia Franzosi,Pamela Linksted,Fiona Green,Asif Rasheed,Moazzam Zaidi,Nabi Shah,Maria Samuel,Nadeem Hayat Mallick,Muhammad Azhar,Khan Shah Zaman,Abdus Samad,M. Ishaq,Ali Raza Gardezi,Fazal-ur-Rehman Memon,Philippe M. Frossard,Tim D. Spector,Leena Peltonen,Leena Peltonen,Markku S. Nieminen,Juha Sinisalo,Veikko Salomaa,Samuli Ripatti,Derrick A Bennett,Karin Leander,Bruna Gigante,Ulf de Faire,Silvia Pietri,Francesca Gori,Roberto Marchioli,Suthesh Sivapalaratnam,John J.P. Kastelein,Mieke D. Trip,Eirini V. Theodoraki,George V. Dedoussis,Engert Jc,Salim Yusuf,Sonia S. Anand +110 more
TL;DR: Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD), a modest number considering the apparent heritability of CAD(8) as mentioned in this paper.
Journal ArticleDOI
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease
Adam S. Butterworth,Peter S. Braund,Martin Farrall,Robert J. Hardwick,Danish Saleheen,J F Peden,Nicole Soranzo,John C. Chambers,Suthesh Sivapalaratnam,Marcus E. Kleber,Brendan J. Keating,Atif Qasim,Norman Klopp,Jeanette Erdmann,Themistocles L. Assimes,Stephen G. Ball,Anthony J. Balmforth,Timothy A. Barnes,Hanneke Basart,Jens Baumert,Connie R. Bezzina,Eric Boerwinkle,Bernhard O. Boehm,Jessy Brocheton,Peter Bugert,François Cambien,Robert Clarke,Veryan Codd,Rory Collins,David Couper,L. Adrienne Cupples,Jonas S.S.G. de Jong,Patrick Diemert,Kenechi Ejebe,Clara C. Elbers,Paul Elliott,Myriam Fornage,Maria Grazia Franzosi,Philippe M. Frossard,Stephen F. Garner,Anuj Goel,Alison H. Goodall,Christian Hengstenberg,Sarah E. Hunt,John J.P. Kastelein,Olaf H. Klungel,Harald Klüterr,Kerstin Koch,Inke R. König,Angad S. Kooner,Reijo Laaksonen,Mark Lathrop,Mingyao Li,Kiang Liu,Ruth McPherson,Muntaser D. Musameh,Solomon K. Musani,Christopher P. Nelson,Christopher J. O'Donnell,Halit Ongen,George J. Papanicolaou,Annette Peters,Bas J M Peters,Simon C. Potter,Bruce M. Psaty,Liming Qu,Daniel J. Rader,Asif Rasheed,Catherine M. Rice,James Scott,Udo Seedorf,Joban Sehmi,Nona Sotoodehnia,Klaus Stark,Jonathan Stephens,C. Ellen van der Schoot,Yvonne T. van der Schouw,Unnur Thorsteinsdottir,Maciej Tomaszewski,Pim van der Harst,Ramachandran S. Vasan,Arthur A.M. Wilde,Christina Willenborg,Bernhard R. Winkelmann,Moazzam Zaidi,Weihua Zhang,Andreas Ziegler,Paul I.W. de Bakker,Wolfgang Koenig,Winfried März,Mieke D. Trip,Muredach P. Reilly,Sekar Kathiresan,Heribert Schunkert,Anders Hamsten,Alistair S. Hall,Jaspal S. Kooner,Simon G. Thompson,John R. Thompson,Panos Deloukas,Willem H. Ouwehand,Hugh Watkins,John Danesh,Nilesh J. Samani,Timothy A. Barnes,Timothy A. Barnes,Suzanne Rafelt,Nienke Bruinsma,Lukas R.C. Dekker,José P. Henriques,Karel T. Koch,Karel T. Koch,Robbert J. de Winter,Marco Alings,Cor F. Allaart,Anton P.M. Gorgels,Freek W. Verheugt,Martina Mueller,Christa Meisinger,Stephanie DerOhannessian,Nehal N. Mehta,Jane F. Ferguson,Hakon Hakonarson,William H. Matthai,Robert L. Wilensky,Jemma C. Hopewell,Sarah Parish,Pamela Linksted,J. Notman,Hector M. González,A. Young,T. Ostley,A. Munday,N. Goodwin,V. Verdon,Svati H. Shah,Laura K. Cobb,Cathryn Edwards,Carol A. Mathews,R. Gunter,J. Benham,Christopher Davies,M. Cobb,J. Crowther,Arthur Mark Richards,M. Silver,S. Tochlin,S. Mozley,Sarah Clark,M. Radley,K. Kourellias,Per Georg Olsson,Simona Barlera,Gianni Tognoni,Stephan Rust,Gerd Assmann,Simon Heath,Diana Zelenika,Ivo Gut,Fiona Green,John F. Peden,Anette Aly,Karolina Anner,Karin Björklund,Gun Blomgren,Barbro Cederschiöld,Karin Danell-Toverud,Per Eriksson,Ulla Grundstedt,Merja Heinonen,Mai Lis Hellénius,Ferdinand M. van't Hooft,Karin Husman,Jacob Lagercrantz,Anita Larsson,Malin Larsson,Magnus Mossfeldt,Anders Mälarstig,Gunnar O Olsson,Maria Sabater-Lleal,Bengt Sennblad,Angela Silveira,Rona J. Strawbridge,Birgitta Söderholm,John Öhrvik,Khan Shah Zaman,Nadeem Hayat Mallick,Muhammad Azhar,Abdus Samad,M. Ishaq,Nabi Shah,Maria Samuel,Muredach P. Reilly,Muredach P. Reilly,Hilma Holm,Michael Preuss,Alexandre F.R. Stewart,Maja Barbalić,Christian Gieger,Devin Absher,Zouhair Aherrahrou,Hooman Allayee,David Altshuler,Sonia S. Anand,Karl Andersen,Jeffrey L. Anderson,Diego Ardissino,Lewis C. Becker,Diane M. Becker,Klaus Berger,Joshua C. Bis,S. Matthijs Boekholdt,Morris J. Brown,Mary Susan Burnett,Ian Buysschaert,John F. Carlquist,Li Chen,Robert W. Davies,George Dedoussis,Abbas Dehghan,Serkalem Demissie,Joseph M. Devaney,Ron Do,Angela Doering,Nour Eddine El Mokhtari,Stephen G. Ellis,Roberto Elosua,James C. Engert,Stephen E. Epstein,Ulf de Faire,Marcus Fischer,Aaron R. Folsom,Jennifer Freyer,Bruna Gigante,Domenico Girelli,Solveig Gretarsdottir,Vilmundur Gudnason,Jeffrey R. Gulcher,Stephanie Tennstedt,Eran Halperin,Naomi Hammond,Stanley L. Hazen,Albert Hofman,Benjamin D. Horne,Thomas Illig,Carlos Iribarren,Gregory T. Jones,J. Wouter Jukema,Michael A. Kaiser,Lee M. Kaplan,Kay-Tee Khaw,Joshua W. Knowles,G. Kolovou,Augustine Kong,Diether Lambrechts,Karin Leander,Wolfgang Lieb,Guillaume Lettre,Christina Loley,Andrew J. Lotery,Pier Mannuccio Mannucci,Seraya Maouche,Nicola Martinelli,Pascal P. McKeown,Thomas Meitinger,Olle Melander,Pier Angelica Merlini,Vincent Mooser,Thomas M. Morgan,Thomas W. Mühleisen,Joseph B. Muhlestein,Kiran Musunuru,Janja Nahrstaedt,Markus M. Nöthen,Oliviero Olivieri,Flora Peyvandi,Riyaz S. Patel,Christopher Patterson,Arshed A. Quyyumi,Loukianos S. Rallidis,Frits R. Roosendaal,Diana Rubin,Veikko Salomaa,M. Lourdes Sampietro,M. S. Sandhu,Eric E. Schadt,Arne Schäfer,Arne Schillert,Stefan Schreiber,Jürgen Schrezenmeir,Stephen M. Schwartz,David S. Siscovick,Mohan U. Sivananthan,Albert V. Smith,Tamara B. Smith,Jaapjan D. Snoep,John A. Spertus,Kari Stefansson,Kathy Stirrups,Monika Stoll,W.H. Wilson Tang,Gudmundur Thorgeirsson,Gudmar Thorleifsson,André G. Uitterlinden,Andre M. van Rij,Benjamin F. Voight,Nicholas J. Wareham,George A. Wells,H.-Erich Wichmann,Jaqueline C M Witteman,Benjamin J. Wright,Shu Ye,Thomas Quertermous,Stefan Blankenberg,Robert Roberts,N. Charlotte Onland-Moret,Jessica van Setten,W. M. Monique Verschuren,Jolanda M. A. Boer,Cisca Wijmenga,Marten H. Hofker,Anke-Hilse Maitland-van der Zee,Anthonius de Boer,Diederick E. Grobbee,Tony Attwood,Stephanie Belz,Peter S. Braund,Peter S. Braund,Jason D. Cooper,Abi Crisp-Hihn,Nicola Foad,Jay Gracey,Emma Gray,Rhian Gwilliams,Susanne Heimerl,Jennifer Jolley,Unni Krishnan,Heather Lloyd-Jones,Ingrid Lugauer,Per Lundmark,Jasbir S. Moore,David Muir,Elizabeth Murray,Jessica Neudert,David Niblett,Karen O'Leary,Helen Pollard,Angela Rankin,Catherine M. Rice,Hendrik B. Sager,Jennifer G. Sambrook,Gerd Schmitz,Michael Scholz,Laura Schroeder,Ann Christine Syvannen,Chris Wallace +355 more
TL;DR: This large-scale gene-centric analysis has identified several novel genes for CAD that relate to diverse biochemical and cellular functions and clarified the literature with regard to many previously suggested genes.
Journal ArticleDOI
The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia
Danish Saleheen,Danish Saleheen,Moazzam Zaidi,Asif Rasheed,Usman Ahmad,Abdul Hakeem,Muhammed Murtaza,Waleed T. Kayani,Azhar Faruqui,Assadullah Kundi,Khan Shah Zaman,Zia Yaqoob,Liaquat Ali Cheema,Abdus Samad,Syed Zahed Rasheed,Nadeem Hayat Mallick,Muhammad Azhar,Rashid Jooma,Ali Raza Gardezi,Nazir Ahmed Memon,Abdul Ghaffar,Fazal-ur-Rehman,Nadir Khan,Nabi Shah,Asad Ali Shah,Maria Samuel,Farina Hanif,Madiha Yameen,Sobia Naz,Aisha Sultana,Aisha Nazir,Shehzad Raza,Muhammad Shazad,Sana Nasim,Muhammad Javed,Syed Saadat Ali,Mehmood Jafree,Muhammad Imran Nisar,Muhammad Salman Daood,Altaf Hussain,Nadeem Sarwar,Ayeesha Kamran Kamal,Panos Deloukas,Muhammad Ishaq,Philippe M. Frossard,John Danesh +45 more
TL;DR: A large epidemiological resource for CHD in South Asia is established and its further expansion and enrichment will be systematically harvested to help identify and evaluate genetic and other determinants of MI in South India.
Journal ArticleDOI
Association of the 9p21.3 Locus With Risk of First-Ever Myocardial Infarction in Pakistanis Case-Control Study in South Asia and Updated Meta-Analysis of Europeans
Danish Saleheen,Myriam Alexander,Asif Rasheed,David Wormser,Nicole Soranzo,Naomi Hammond,Adam S. Butterworth,Moazzam Zaidi,Philip Haycock,Suzannah Bumpstead,Simon C. Potter,Hannah Blackburn,Emma Gray,Emanuele Di Angelantonio,Stephen Kaptoge,Nabi Shah,Maria Samuel,Ahmedyar Janjua,Nasir Sheikh,Shajjia Razi Haider,Muhammed Murtaza,Usman Ahmad,Abdul Hakeem,Muhammad Ali Memon,Nadeem Hayat Mallick,Muhammad Azhar,Abdus Samad,Syed Zahed Rasheed,Ali Raza Gardezi,Nazir Ahmed Memon,Abdul Ghaffar,Fazal-ur-Rehman Memon,Khan Shah Zaman,Assadullah Kundi,Zia Yaqoob,Liaquat Ali Cheema,Nadeem Qamar,Azhar Faruqui,Rashid Jooma,Jawaid Hassan Niazi,Mustafa Hussain,Kishore Kumar,Asim Saleem,Kishwar Kumar,Muhammad Salman Daood,Fatima Memon,Aftab Alam Gul,Shahid Abbas,Junaid Zafar,Faisal Shahid,Zehra Memon,Shahzad Majeed Bhatti,Waleed T. Kayani,Syed Saadat Ali,Muhammad Fahim,Muhammad Ishaq,Philippe M. Frossard,Panos Deloukas,John Danesh +58 more
TL;DR: This study provides the first demonstration that variants at the 9p21 locus are significantly associated with MI risk in Pakistanis, however, association signals at this locus were weaker in Pakistani than those in European studies.
Profile of acute myocardial infarction (ami) in pakistan
TL;DR: The emerging profile of patients with AMI is that the majority are male, relatively younger as compared to Western population, have smoking and hypertension followed by diabetes as the major risk factors.