S
Stephan Sauer
Researcher at Imperial College London
Publications - 15
Citations - 6014
Stephan Sauer is an academic researcher from Imperial College London. The author has contributed to research in topics: Cellular differentiation & Chromatin. The author has an hindex of 13, co-authored 15 publications receiving 5708 citations. Previous affiliations of Stephan Sauer include National Institutes of Health & Research Institute of Molecular Pathology.
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Journal ArticleDOI
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Antoine H.F.M. Peters,Dónal O'Carroll,Harry Scherthan,Karl Mechtler,Stephan Sauer,Christian Schöfer,Klara Weipoltshammer,Michaela Pagani,Monika Lachner,Alexander Kohlmaier,Susanne Opravil,Michael P. Doyle,Maria Sibilia,Thomas Jenuwein +13 more
TL;DR: In vivo data assign a crucial role for pericentric H3-K9 methylation in protecting genome stability, and define the Suv39h HMTases as important epigenetic regulators for mammalian development.
Journal ArticleDOI
Chromatin signatures of pluripotent cell lines
Véronique Azuara,Pascale Perry,Stephan Sauer,Mikhail Spivakov,Helle F. Jørgensen,Rosalind M. John,Rosalind M. John,Mina Gouti,Mina Gouti,Miguel Casanova,Gary Warnes,Matthias Merkenschlager,Amanda G. Fisher +12 more
TL;DR: It is shown that the epigenetic profile of pluripotent embryonic stem cells (ES) is distinct from that of embryonic carcinoma cells, haematopoietic stem cells and their differentiated progeny, and that lineage-specific genes are primed for expression in ES cells but are held in check by opposing chromatin modifications.
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Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms
Vania Parelho,Suzana Hadjur,Mikhail Spivakov,Marion Leleu,Stephan Sauer,Heather C. Gregson,Adam Jarmuz,Claudia Canzonetta,Zoe Webster,Tatyana B. Nesterova,Bradley S. Cobb,Kyoko Yokomori,Niall Dillon,Luis Aragón,Amanda G. Fisher,Matthias Merkenschlager +15 more
TL;DR: It is shown that the distribution of cohesins on mammalian chromosome arms is not driven by transcriptional activity, in contrast to S. cerevisiae, and recruitment by CTCF suggests a rationale for noncanonical cohesin functions and, because C TCF binding is sensitive to DNA methylation, allows cohesIn positioning to integrate DNA sequence and epigenetic state.
Journal ArticleDOI
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
Stephan Sauer,Ludovica Bruno,Arnulf Hertweck,David K. Finlay,Marion Leleu,Mikhail Spivakov,Zachary A. Knight,Bradley S. Cobb,Doreen A. Cantrell,Eric D. O'Connor,Kevan M. Shokat,Amanda G. Fisher,Matthias Merkenschlager +12 more
TL;DR: It is demonstrated that the PI3K/Akt/mTOR signaling network regulates Foxp3 expression, and premature termination of TCR signaling and inibition of phosphatidyl inositol 3-kinase (PI3K) p110α, p110δ, protein kinase B (Akt), or mammalian target of rapamycin (mTOR) conferred Foxp 3 expression and Treg-like gene expression profiles.
Journal ArticleDOI
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators
David Landeira,Stephan Sauer,Raymond A. Poot,Maria Dvorkina,Luca Mazzarella,Helle F. Jørgensen,C. Filipe Pereira,Marion Leleu,Francesco M. Piccolo,Mikhail Spivakov,Emily Brookes,Ana Pombo,Cynthia L. Fisher,Cynthia L. Fisher,William C. Skarnes,Tim Snoek,Karel Bezstarosti,Jeroen Demmers,Robert J. Klose,Miguel Casanova,Lígia Tavares,Neil Brockdorff,Matthias Merkenschlager,Amanda G. Fisher +23 more
TL;DR: Jarid2 is a novel subunit of PRC2 that is required for the co-recruitment ofPRC1 and RNAP to genes that regulate development in ES cells, and suggests that priming is critical for subsequent multi-lineage differentiation.