S
S. Van Gassen
Researcher at Ghent University
Publications - 5
Citations - 192
S. Van Gassen is an academic researcher from Ghent University. The author has contributed to research in topics: Immune dysregulation & Immune system. The author has an hindex of 2, co-authored 5 publications receiving 40 citations.
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Journal ArticleDOI
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity.
Lore Vanderbeke,P. Van Mol,Y. Van Herck,F. De Smet,Stephanie Humblet-Baron,Kimberly Martinod,Asier Antoranz,Ingrid Arijs,Bram Boeckx,Francesca Maria Bosisio,M. Casaer,Dieter Dauwe,W. De Wever,Christophe Dooms,Erwin Dreesen,A. Emmaneel,J. Filtjens,M. Gouwy,Jan Gunst,Greet Hermans,Steven Jansen,Katrien Lagrou,Adrian Liston,N. Lorent,Philippe Meersseman,Toine Mercier,Johan Neyts,J. Odent,Dena Panovska,P. A. Penttila,E. Pollet,Paul Proost,Junbin Qian,K. Quintelier,Jeroen Raes,S. Rex,Yvan Saeys,Jenny Sprooten,Sabine Tejpar,Dries Testelmans,Karin Thevissen,T. Van Buyten,J. Vandenhaute,S. Van Gassen,L. C. Velásquez Pereira,R. Vos,Birgit Weynand,A. Wilmer,Jonas Yserbyt,Abhishek D. Garg,Patrick Matthys,Carine Wouters,D Lambrechts,Els Wauters,Joost Wauters +54 more
TL;DR: A myeloid-driven immunopathology is suggested, in which hyperactivated neutrophils and an ineffective adaptive immune system act as mediators of COVID-19 disease severity.
Journal ArticleDOI
A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation
Simon Tavernier,Simon Tavernier,Vicki Athanasopoulos,Vicki Athanasopoulos,Patrick Verloo,Gesine Behrens,Jens Staal,Delfien Bogaert,Leslie Naesens,M. A. A. De Bruyne,S. Van Gassen,Eef Parthoens,Julia I. Ellyard,Jean Cappello,L. X. Morris,H. Van Gorp,G. Van Isterdael,Yvan Saeys,M. Lamkanfi,Petra Schelstraete,Joke Dehoorne,Victoria Bordon,R. Van Coster,Bart N. Lambrecht,Bart N. Lambrecht,Björn Menten,Rudi Beyaert,Carola G. Vinuesa,Carola G. Vinuesa,Vigo Heissmeyer,Melissa Dullaers,Melissa Dullaers,Filomeen Haerynck +32 more
TL;DR: It is suggested that impaired Roquin-1 function provokes hyperinflammation by a failure to quench immune activation, which is a posttranscriptional regulator that controls the expression of many immune-related genes such as ICOS and TNFA.
Journal ArticleDOI
High dimensional profiling identifies specific immune types along the recovery trajectories of critically ill COVID19 patients.
P. A. Penttila,S. Van Gassen,Dena Panovska,Lore Vanderbeke,Y. Van Herck,K. Quintelier,A. Emmaneel,J. Filtjens,Bert Malengier-Devlies,Kourosh Ahmadzadeh,P. Van Mol,D. M. Borràs,Asier Antoranz,Francesca Maria Bosisio,Els Wauters,Kimberly Martinod,Patrick Matthys,Yvan Saeys,Abhishek D. Garg,Joost Wauters,F. De Smet +20 more
TL;DR: In this paper, the authors have analyzed whole blood samples serially collected from 40 surviving COVID-19 patients throughout their recovery in ICU using high-dimensional cytometry by time-of-flight (CyTOF) and cytokine multiplexing.
Journal ArticleDOI
Monocyte-Driven Atypical Cytokine Storm and Aberrant Neutrophil Activation as Key Mediators of COVID19 Disease Severity
Lore Vanderbeke,Pierre Van Mol,Y. Van Herck,F. De Smet,Stephanie Humblet-Baron,Kimberly Martinod,Asier Antoranz,Ingrid Arijs,Bram Boeckx,Francesca Maria Bosisio,M. Casaer,Dieter Dauwe,W. De Wever,Christophe Dooms,Erwin Dreesen,A. Emmaneel,J. Filtjens,M. Gouwy,Jan Gunst,Greet Hermans,Sander Jansen,Katrien Lagrou,Adrian Liston,N. Lorent,Philippe Meersseman,Toine Mercier,Johan Neyts,J. Odent,Dena Panovska,P. A. Penttila,E. Pollet,Paul Proost,Junbin Qian,K. Quintelier,Jeroen Raes,S. Rex,Yvan Saeys,Jenny Sprooten,Sabine Tejpar,Dries Testelmans,Karin Thevissen,T. Van Buyten,J. Vandenhaute,S. Van Gassen,L. C. Velásquez Pereira,R. Vos,Birgit Weynand,A. Wilmer,Jonas Yserbyt,Abhishek D. Garg,Patrick Matthys,Carine Wouters,Diether Lambrechts,Els Wauters,Joost Wauters +54 more
TL;DR: In this paper, the host immune response in symptomatic COVID-19 patients seems ineffective in clearing SARS-CoV-2, yet excessive in causing local tissue damage and hypercytokinemia.
Journal ArticleDOI
Author Correction: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.
Simon Tavernier,Simon Tavernier,Vicki Athanasopoulos,Vicki Athanasopoulos,Patrick Verloo,Gesine Behrens,Jens Staal,Delfien Bogaert,Leslie Naesens,M. A. A. De Bruyne,S. Van Gassen,Eef Parthoens,Julia I. Ellyard,Jean Cappello,L. X. Morris,H. Van Gorp,G. Van Isterdael,Yvan Saeys,M. Lamkanfi,Petra Schelstraete,Joke Dehoorne,Victoria Bordon,R. Van Coster,Bart N. Lambrecht,Bart N. Lambrecht,Björn Menten,Rudi Beyaert,Carola G. Vinuesa,Carola G. Vinuesa,Vigo Heissmeyer,Melissa Dullaers,Melissa Dullaers,Filomeen Haerynck +32 more
TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.