Sung-il Yoon

TL;DR: Sil-MA bioink created from silk fibroin (SF) for digital light processing (DLP) 3D bioprinting in tissue engineering applications allowed us to build highly complex organ structures with excellent structural stability and reliable biocompatibility.

TL;DR: The crystal structure of zebrafish TLR5 (as a variable lymphocyte receptor hybrid protein) in complex with the D1/D2/D3 fragment of Salmonella flagellin, FliC, is determined at 2.47 angstrom resolution.

TL;DR: The crystal structure of 5J8 Fab in complex with a bacterially expressed and refolded globular head domain from the hemagglutinin (HA) of the A/California/07/2009 (H1N1) pandemic virus is presented and consistent with previous studies, the bacterially expression H1 HA properly refolds, retaining its antigenic structure, and presents a low-cost and rapid alternative for engineering and manufacturing candidate flu vaccines.

TL;DR: Interestingly, IL-10R2 binding residues located in the N-terminal end of helix A exhibit large structural differences between unbound cil-10 and cIL-10·IL- 10R1 crystal structures, which suggests IL-9R1-induced conformational changes regulate IL-11R2binding and assembly of the ternary IL- 10·IL -10R1·ILR2 complex.

TL;DR: This work provides a conserved structural mechanism by which flagellins from Gram-negative γ-proteobacteria and Gram-positive Firmicutes bacteria bind and activate Toll-like receptor 5 (TLR5) and establishes the groundwork for the future design of flageLLin-based therapeutics.