S
Susan Thrane
Researcher at University of Copenhagen
Publications - 23
Citations - 899
Susan Thrane is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Plasmodium falciparum & Antigen. The author has an hindex of 12, co-authored 22 publications receiving 667 citations. Previous affiliations of Susan Thrane include Copenhagen University Hospital.
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Journal ArticleDOI
Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
Ali Salanti,Thomas Mandel Clausen,Mette Ø. Agerbæk,Nader Al Nakouzi,Nader Al Nakouzi,Madeleine Dahlbäck,Htoo Zarni Oo,Htoo Zarni Oo,Sherry Lee,Tobias Gustavsson,Jamie R. Rich,Bradley John Hedberg,Yang Mao,Line Barington,Marina Ayres Pereira,Janine LoBello,Makoto Endo,Ladan Fazli,Jo Soden,Chris K. Wang,Adam F. Sander,Robert Dagil,Susan Thrane,Peter Johannes Holst,Le Meng,Francesco Favero,Glen J. Weiss,Glen J. Weiss,Morten Nielsen,Jim Freeth,Torsten O. Nielsen,Joseph Zaia,Nhan L. Tran,Jeff Trent,John Babcook,Thor G. Theander,Poul H. Sorensen,Mads Daugaard,Mads Daugaard +38 more
TL;DR: The data demonstrate how an evolutionarily refined parasite-derived protein can be exploited to target a common, but complex, malignancy-associated glycosaminoglycan modification.
Journal ArticleDOI
Bacterial superglue enables easy development of efficient virus-like particle based vaccines
Susan Thrane,Susan Thrane,Christoph M. Janitzek,Christoph M. Janitzek,Sungwa Matondo,Mafalda Resende,Mafalda Resende,Tobias Gustavsson,Tobias Gustavsson,Willem A. de Jongh,Stine N. Clemmensen,Stine N. Clemmensen,Stine N. Clemmensen,Will Roeffen,Marga van de Vegte‑Bolmer,Geert-Jan van Gemert,Robert W. Sauerwein,John T. Schiller,Morten Nielsen,Morten Nielsen,Thor G. Theander,Thor G. Theander,Ali Salanti,Ali Salanti,Adam F. Sander,Adam F. Sander +25 more
TL;DR: The spy-VLP system constitutes a versatile and rapid method to develop highly immunogenic VLP-based vaccines and could facilitate rapid and unbiased screening of vaccine candidate antigens.
Journal ArticleDOI
Virus-like particle display of HER2 induces potent anti-cancer responses
Arianna Palladini,Susan Thrane,Christoph M. Janitzek,Jessica Pihl,Stine B. Clemmensen,Stine B. Clemmensen,Willem A. de Jongh,Thomas Mandel Clausen,Giordano Nicoletti,Lorena Landuzzi,Manuel L. Penichet,Tania Balboni,Marianna L. Ianzano,Veronica Giusti,Thor G. Theander,Morten Nielsen,Ali Salanti,Pier Luigi Lollini,Patrizia Nanni,Adam F. Sander +19 more
TL;DR: Using a novel virus-like particle (VLP) based vaccine platform, it is shown that directional, high-density display of human HER2 on the surface of VLPs, allows induction of therapeutically potent anti-HER2 autoantibody responses.
Journal ArticleDOI
Estrogen receptor α is the major driving factor for growth in tamoxifen-resistant breast cancer and supported by HER/ERK signaling
Susan Thrane,Anne E. Lykkesfeldt,Mathilde S. Larsen,Boe Sandahl Sorensen,Christina Westmose Yde +4 more
TL;DR: Combined treatment against ERα and ERK signaling in resistant cells was superior to single-agent treatment and as effective as fulvestrant treatment of MCF-7 cells, implying that combined targeting of these pathways may have a clinical potential for overcoming tamoxifen resistance.
Journal ArticleDOI
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity.
Cyrielle Fougeroux,Louise Goksøyr,Manja Idorn,Vladislav Soroka,Sebenzile K. Myeni,Robert Dagil,Christoph M. Janitzek,Max Søgaard,Kara Lee Aves,Emma W. Horsted,Sayit Mahmut Erdoğan,Sayit Mahmut Erdoğan,Tobias Gustavsson,Jerzy Dorosz,Stine B. Clemmensen,Laurits Fredsgaard,Susan Thrane,Elena Ethel Vidal-Calvo,Paul Khalifé,Thomas M. Hulen,Swati Choudhary,Michael Theisen,Susheel K. Singh,Asier Garcia-Senosiain,Linda van Oosten,Gorben P. Pijlman,Bettina Hierzberger,Tanja Domeyer,Blanka W. Nalewajek,Anette Strøbæk,Magdalena Skrzypczak,Laura F. Andersson,Søren Buus,Anette Stryhn Buus,Jan Pravsgaard Christensen,Tim J. Dalebout,Kasper Iversen,Lene Holm Harritshøj,Benjamin Mordmüller,Henrik Ullum,Line S. Reinert,Willem A. de Jongh,Marjolein Kikkert,Søren R. Paludan,Thor G. Theander,Morten Nielsen,Ali Salanti,Adam F. Sander +47 more
TL;DR: In this paper, two capsid-like particle (CLP)-based vaccines displaying the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein were developed.