S
Susheel K. Singh
Researcher at University of Copenhagen
Publications - 67
Citations - 1196
Susheel K. Singh is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 18, co-authored 47 publications receiving 781 citations. Previous affiliations of Susheel K. Singh include Statens Serum Institut & Copenhagen University Hospital.
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Journal ArticleDOI
A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stages.
Michael Theisen,Will Roeffen,Susheel K. Singh,Susheel K. Singh,Gorm Andersen,Linda E. Amoah,Marga van de Vegte-Bolmer,Theo Arens,Régis Wendpayangde Tiendrebeogo,Régis Wendpayangde Tiendrebeogo,Sophie Jones,Teun Bousema,Teun Bousema,Bright Adu,Bright Adu,Morten Hanefeld Dziegiel,Michael Christiansen,Robert W. Sauerwein +17 more
TL;DR: Specific antibodies showed strong transmission blocking activity against multiple Pf-strains in the standard membrane feeding assay and functional activity against asexual stages in the antibody dependent cellular inhibition assay, which provide a strong rationale for entering the next phase of clinical grade production and testing.
Journal ArticleDOI
Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
Will Stone,Will Stone,Joseph J. Campo,André Lin Ouédraogo,Lisette Meerstein-Kessel,Isabelle Morlais,Dari Da,Anna Cohuet,Sandrine E. Nsango,Colin J. Sutherland,Marga van de Vegte-Bolmer,Rianne Siebelink-Stoter,Geert-Jan van Gemert,Wouter Graumans,Kjerstin Lanke,Adam D. Shandling,Jozelyn Pablo,Andy Teng,Sophie Jones,Roos M. de Jong,Amanda Fabra-García,John S. Bradley,Will Roeffen,Edwin Lasonder,Giuliana Gremo,Evelin Schwarzer,Chris J. Janse,Susheel K. Singh,Susheel K. Singh,Michael Theisen,Michael Theisen,Phil Felgner,Matthias Marti,Matthias Marti,Chris Drakeley,Robert W. Sauerwein,Teun Bousema,Teun Bousema,Matthijs M. Jore +38 more
TL;DR: It is demonstrated that host antibody responses to gametocyte proteins are associated with reduced malaria transmission efficiency from humans to mosquitoes.
Journal ArticleDOI
The Malaria Vaccine Candidate GMZ2 Elicits Functional Antibodies in Individuals From Malaria Endemic and Non-Endemic Areas
Micha Phill Grønholm Jepsen,Micha Phill Grønholm Jepsen,Prajakta S. Jogdand,Prajakta S. Jogdand,Susheel K. Singh,Meral Esen,Michael Christiansen,Saadou Issifou,Aurore Bouyoukou Hounkpatin,Ulysse Ateba-Ngoa,Peter G. Kremsner,Morten Hanefeld Dziegiel,Severin Olesen-Larsen,Søren Jepsen,Benjamin Mordmüller,Michael Theisen,Michael Theisen +16 more
TL;DR: It is suggested that GMZ2 adjuvanted in Al(OH)3 elicits high levels of specific and functional antibodies with the capacity to control parasite multiplication.
Journal ArticleDOI
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity.
Cyrielle Fougeroux,Louise Goksøyr,Manja Idorn,Vladislav Soroka,Sebenzile K. Myeni,Robert Dagil,Christoph M. Janitzek,Max Søgaard,Kara Lee Aves,Emma W. Horsted,Sayit Mahmut Erdoğan,Sayit Mahmut Erdoğan,Tobias Gustavsson,Jerzy Dorosz,Stine B. Clemmensen,Laurits Fredsgaard,Susan Thrane,Elena Ethel Vidal-Calvo,Paul Khalifé,Thomas M. Hulen,Swati Choudhary,Michael Theisen,Susheel K. Singh,Asier Garcia-Senosiain,Linda van Oosten,Gorben P. Pijlman,Bettina Hierzberger,Tanja Domeyer,Blanka W. Nalewajek,Anette Strøbæk,Magdalena Skrzypczak,Laura F. Andersson,Søren Buus,Anette Stryhn Buus,Jan Pravsgaard Christensen,Tim J. Dalebout,Kasper Iversen,Lene Holm Harritshøj,Benjamin Mordmüller,Henrik Ullum,Line S. Reinert,Willem A. de Jongh,Marjolein Kikkert,Søren R. Paludan,Thor G. Theander,Morten Nielsen,Ali Salanti,Adam F. Sander +47 more
TL;DR: In this paper, two capsid-like particle (CLP)-based vaccines displaying the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein were developed.
Journal ArticleDOI
Improving the malaria transmission-blocking activity of a Plasmodium falciparum 48/45 based vaccine antigen by SpyTag/SpyCatcher mediated virus-like display.
Susheel K. Singh,Susan Thrane,Christoph M. Janitzek,Morten Nielsen,Thor G. Theander,Michael Theisen,Michael Theisen,Michael Theisen,Ali Salanti,Adam F. Sander,Adam F. Sander +10 more
TL;DR: The study demonstrates that VLP-display of R0.6C and 6C significantly increases antigen immunogenicity when using Montanide ISA 720 VG as extrinsic adjuvant.