S
Susumu Kobayashi
Researcher at Beth Israel Deaconess Medical Center
Publications - 648
Citations - 23408
Susumu Kobayashi is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Total synthesis & Epidermal growth factor receptor. The author has an hindex of 62, co-authored 629 publications receiving 21514 citations. Previous affiliations of Susumu Kobayashi include Chiba University & University of Tokyo.
Papers
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Journal ArticleDOI
TAS2940, a novel brain‐penetrable pan‐ERBB inhibitor, for tumors with HER2 and EGFR aberrations
Kei Oguchi,Hikari Araki,Shingo Tsuji,Masayuki Nakamura,Akihiro Miura,Kaoru Funabashi,Akiko Osada,Sakiho Tanaka,Takamasa Suzuki,Susumu Kobayashi,Shinji Mizuarai +10 more
TL;DR: TAS2940 has promising therapeutic effects in preclinical study against cancers harboring HER2/EGFR mutations, especially metastatic and primary brain tumors, and the results highlight potential novel strategies against lung cancers with brain metastases harboring Her2/ EGFR ex20 insertions and glioblastomas with EGFR aberrations.
Journal ArticleDOI
Total Synthesis of Khafrefungin Using Highly Stereoselective Vinylogous Mukaiyama Aldol Reaction.
Shin-ichi Shirokawa,Mariko Shinoyama,Isao Ooi,Seijiro Hosokawa,Atsuo Nakazaki,Susumu Kobayashi +5 more
TL;DR: In this article, a convergent total synthesis of khafrefungin was accomplished on the basis of the highly stereoselective TiCl4-mediated Mukaiyama aldol reaction using vinylketene silyl N,O-acetal and syn-selective anneal 5a and ethyl ketone 6 followed by anti-dehydration under Mitsunobu conditions.
Journal ArticleDOI
Synthesis of 4-(Methoxyethyl) Monobactams by a Chemicoenzymatic Approach.
TL;DR: In this paper, a key intermediate for the synthesis of monobactam analogues, cis-3-benzyloxycarbonyl-amino-4-(2-hydroxyehtyl)-2-azetidinone was synthesized from (4S)-4-methoxy carbonylmethyl-2-enzyloxy-acetamido, and converted into monobacts having a methoxyethyl group at the C-4 position of the β-lactam ring.
Journal ArticleDOI
Molecular design of biologically active compounds based on platelet activating factor (PAF): 7-oxabicyclo[2.2.1]heptane system as a strong antagonist of PAF.
TL;DR: Among four stereoisomers synthesized, the diexo derivative turned out to be a new and strong antagonist of PAF.
Patent
Production of alpha-aminophosphonic acid derivative
TL;DR: In this article, an aldehyde of the formula R1CHO is reacted with an ammonium salt and a phosphorous diester to obtain the objective alpha-aminophosphonic acid derivative of formula II (e.g. 1-amino-1-phenylmethylphosphonic diethyl hydrochloride).