S
Susumu Kobayashi
Researcher at Beth Israel Deaconess Medical Center
Publications - 648
Citations - 23408
Susumu Kobayashi is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Total synthesis & Epidermal growth factor receptor. The author has an hindex of 62, co-authored 629 publications receiving 21514 citations. Previous affiliations of Susumu Kobayashi include Chiba University & University of Tokyo.
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Efficient synthesis of 3-O-thia-cPA and preliminary analysis of its biological activity toward autotaxin.
Ryo Tanaka,Masaru Kato,Takahiro Suzuki,Atsuo Nakazaki,Emi Nozaki,Mari Gotoh,Kimiko Murakami-Murofushi,Susumu Kobayashi +7 more
TL;DR: The efficient synthesis of 3-O-thia-cPAs (4a-d), sulfur analogues of cyclic phosphatidic acid (cPA), has been achieved and preliminary biological experiments showed that 4a-D exhibited a similar inhibitory effect on autotaxin (ATX) as original cPA.
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Is modified Devine exclusion necessary for gastrojejunostomy in patients with unresectable pancreatobiliary cancer
Teruyuki Usuba,Takeyuki Misawa,Yoichi Toyama,Yuichi Ishida,Yuji Ishii,Satoru Yanagisawa,Susumu Kobayashi,Katsuhiko Yanaga +7 more
TL;DR: Modified Devine exclusion may be effective for patients with unresectable pancreatobiliary cancer, and slowed the progression of anemia in all of the patients with duodenal bleeding.
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Design, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1).
Nobuhiko Fushimi,Hirotaka Teranishi,Kazuo Shimizu,Shigeru Yonekubo,Kohsuke Ohno,Takashi Miyagi,Fumiaki Itoh,Toshihide Shibazaki,Masaki Tomae,Yukiko Ishikawa-Takemura,Takeshi Nakabayashi,Noboru Kamada,Yuji Yamauchi,Susumu Kobayashi,Masayuki Isaji +14 more
TL;DR: Optimized compound 14c showed an improved profile satisfying both higher activity and lower permeability of its aglycone compared with initial leads 1 and 2 and the superior efficacy of 14c in various carbohydrate tolerance tests in diabetic rat models was confirmed compared with acarbose, an α-glucosidase inhibitor widely used in the clinic.
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Stereocontrolled Synthesis of Functionalized Spirocyclic Compounds Based on Claisen Rearrangement and its Application to the Synthesis of Spirocyclic Sesquiterpenes and Pyrrolidinoindoline Alkaloids
Atsuo Nakazaki,Susumu Kobayashi +1 more
TL;DR: A one-pot intramolecular Ullmann coupling (IUC)/Claisen rearrangement sequence from 2-iodoindoles was found to provide spirocyclic oxindoles in good yields with excellent stereoselectivities and was applied to the synthesis of pyrrolidinoindoline alkaloids.
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Preparation of 2-O-(3-O-carbamoyl-α-d-mannopyranosyl)-l-gulopyranose: Synthetic study on the sugar moiety of antitumor antibiotic bleomycin
TL;DR: In this paper, a new practical route to the disaccharide moiety of bleomycin was developed by applying stannylene acetal methodology, and both key building blocks 9 and 16 were prepared from d -mannose in a regioselective manner by applying Stannylene Acetal methodology.