S
Susumu Kobayashi
Researcher at Beth Israel Deaconess Medical Center
Publications - 648
Citations - 23408
Susumu Kobayashi is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Total synthesis & Epidermal growth factor receptor. The author has an hindex of 62, co-authored 629 publications receiving 21514 citations. Previous affiliations of Susumu Kobayashi include Chiba University & University of Tokyo.
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Journal ArticleDOI
Responses to the multitargeted MET/ALK/ROS1 inhibitor crizotinib and co-occurring mutations in lung adenocarcinomas with MET amplification or MET exon 14 skipping mutation.
Susan E. Jorge,Sol Schulman,Jason A. Freed,Paul A. VanderLaan,Deepa Rangachari,Susumu Kobayashi,Mark S. Huberman,Daniel B. Costa +7 more
TL;DR: Nearly 10% of lung adenocarcinomas harbor aberrations that are targetable using the approved multitargeted TKI crizotinib, but co-occurrence of PIK3CA mutation needs to be better evaluated as a modifier of response to TKI therapy.
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Synthetic analogues and biosynthetic intermediates of bleomycin. Metal-binding, dioxygen interaction, and implication for the role of functional groups in bleomycin action mechanism.
TL;DR: The present results support that the beta-aminoalaninepyrimidine-beta-hydroxyhistidine portion of the bleomycin molecule substantially participates in the Fe(II) and dioxygen interactions.
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Steryl glucoside is a lipid mediator in stress-responsive signal transduction.
Shohko Kunimoto,Wataru Murofushi,Wataru Murofushi,Hirofumi Kai,Yoko Ishida,Ayako Uchiyama,Tetsuyuki Kobayashi,Susumu Kobayashi,Hiromu Murofushi,Kimiko Murakami-Murofushi +9 more
TL;DR: Results strongly suggest that CG acts as a mediator in the early stage of stress responsive signal transduction in fibroblast cells by exposure to exogenously added human major SG, cholesteryl glucoside (CG).
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CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer–binding protein alpha
Steffen Koschmieder,Francesco D'Alo',Hanna S. Radomska,Christine Schöneich,Ji Suk Chang,Marina Konopleva,Susumu Kobayashi,Elena Levantini,Nanjoo Suh,Annalisa Di Ruscio,Maria Teresa Voso,Julie C. Watt,Ramasamy Santhanam,Bülent Sargin,Hagop M. Kantarjian,Michael Andreeff,Michael B. Sporn,Danilo Perrotti,Wolfgang E. Berdel,Carsten Müller-Tidow,Hubert Serve,Daniel G. Tenen +21 more
TL;DR: The inclusion of CDDO in the therapy of AML characterized by dysfunctional CEBPA expression is suggested, because AML is characterized by arrested differentiation.
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Synthesis of 2-O-(3-O-carbamoyl-α-d-mannopyranosyl)-l-gulopyranose: Sugar moiety of antitumor antibiotic bleomycin
Tetsuta Oshitari,Masakatsu Shibasaki,Takeshi Yoshizawa,Masahiro Tomita,Ken Ichi Takao,Susumu Kobayashi +5 more
TL;DR: In this article, a new route to the disaccharide moiety (2-O-(3-O-carbamoyl-α-d-mannopyranosyl)-l-gulopyranose) of the antitumor agent bleomycin was developed.