S
Susumu Kobayashi
Researcher at Beth Israel Deaconess Medical Center
Publications - 648
Citations - 23408
Susumu Kobayashi is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Total synthesis & Epidermal growth factor receptor. The author has an hindex of 62, co-authored 629 publications receiving 21514 citations. Previous affiliations of Susumu Kobayashi include Chiba University & University of Tokyo.
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Journal ArticleDOI
Selective inhibition of DNA polymerase-α family with chemically synthesized derivatives of PHYLPA, a unique Physarum lysophosphatidic acid
Kimiko Murakami-Murofushi,Susumu Kobayashi,Kenjiro Onimura,Miyoko Matsumoto,Masaki Shioda,Shorten Yoshida,Mami Shoji,Hiromu Murofushi +7 more
TL;DR: The extent of the inhibition apparently depends on the stereochemistry of both the fatty acid moiety and the cyclic phosphate, and some derivatives having no cyclopropane-containing fatty acids showed inhibition to some extent; but 1-palmytoyl and 1-oleoyl lysophosphatidic acid did not show an apparent inhibitor activity on DNA polymerases.
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Pulse Afatinib for ERBB2 Exon 20 Insertion–Mutated Lung Adenocarcinomas
Daniel B. Costa,Susan E. Jorge,Jason P. Moran,Jason A. Freed,Jessica A. Zerillo,Mark S. Huberman,Susumu Kobayashi +6 more
TL;DR: Pulse afatinib at a weekly dosing scheme induced antitumor activity in ERBB2 exon 20 insertion–mutated lung adenocarcinomas, and future clinical trials of alternative dosing schemes of ERBB TKIs as monotherapy or in combination with other therapies are warranted for ER BB2‐mutated tumors.
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Highly Stereoselective Construction of Spiro[4.5]decanes by SmI2-Promoted Ketyl Radical Mediated Tandem Cyclization
TL;DR: Ketyl radical mediated tandem cyclization of omega-alkynyl carbonyl compounds bearing activated alkene using SmI(2) gave spiro[4.5]decanes stereoselectively.
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Stereoselective synthesis of (2s,3s,4r)-4-amino-3-hydroxy-2-methyl-pentanoic acid, an amino acid constituent of bleomycin, by aldold condensation)☆
Masatoshi Narita,Masami Otsuka,Susumu Kobayashi,Masaji Ohno,Yoji Umezawa,Hajime Morishima,Sei ichi Saito,Tomohisa Takita,Hamao Umezawa +8 more
TL;DR: In this article, a (2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid, a novel amino acid constituent of bleomycin, has been synthesized stereoselectively through aldol condensation of (R)-2-aminopropionaldehyde derivatives and E-vinyloxyboranes.
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EGFR delE709_T710insD: a rare but potentially EGFR inhibitor responsive mutation in non-small-cell lung cancer.
TL;DR: The response to erlotinib of an EGFR delE709_T710insD mutated NSCLC is reported, and a review of the literature on the pattern of response to EGFR TKIs of this mutation type is provided.