S
Susumu Kobayashi
Researcher at Beth Israel Deaconess Medical Center
Publications - 648
Citations - 23408
Susumu Kobayashi is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Total synthesis & Epidermal growth factor receptor. The author has an hindex of 62, co-authored 629 publications receiving 21514 citations. Previous affiliations of Susumu Kobayashi include Chiba University & University of Tokyo.
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Journal ArticleDOI
Synthetic Study on Antitumor Antibiotic Terpentecin: Construction of the Carbobicyclic Decalin Moiety
Ken Ichi Takao,Susumu Kobayashi +1 more
TL;DR: Carbobicyclic decalin moiety of antitumor terpentecin is prepared in a stereoselective manner from (+)-Wieland-Miescher ketone via reductive alkylation and Birch reduction.
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Serum Concentrations of Erlotinib at a Dose of 25 mg Daily
TL;DR: In this paper, the clinical efficacy of erlotinib at a dose of 25 mg daily for patients with metastatic non-small cell lung cancers (NSCLCs) with somatic mutations in the epidermal growth factor receptor (EGFR) gene was reported.
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A convenient method for the transformation of alcohols to alkyl iodides using 2-fluoropyridinium salt.
TL;DR: 1-Methyl-2-alkoxypyridinium salts, easily formed in situ from 1-methyl-2 -fluoropyrinium salt and alcohols, react with sodium iodide to give the corresponding alkyl iodides in good yields.
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Stereoselective 1,5-rearrangement of vinylketene-N,O-acetals: novel vinylogous Ferrier reaction
TL;DR: In this paper, a 1,3- or 1,5-rearrangement of N,O-acetals in dichloromethane was described, and crossover experiments indicated that the reaction proceeded through an ion pair intermediate.
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The stereospecific preparation of trisubstituted olefins
TL;DR: In this paper, the same authors showed that n-butylmagnesium bromide and cuprous iodide can be obtained in high yield with the perfect retention of configuration.