S
Svenja Simonyi
Researcher at Goethe University Frankfurt
Publications - 6
Citations - 166
Svenja Simonyi is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Xenorhabdus & Photorhabdus. The author has an hindex of 4, co-authored 6 publications receiving 106 citations.
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Journal ArticleDOI
Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus
Nicholas J. Tobias,Hendrik Wolff,Bardya Djahanschiri,Florian Grundmann,Max Kronenwerth,Yi-Ming Shi,Svenja Simonyi,Peter Grün,David I. Shapiro-Ilan,Sacha J. Pidot,Timothy P. Stinear,Ingo Ebersberger,Helge B. Bode +12 more
TL;DR: Comparative genomics and high-resolution mass spectrometry reveal the biosynthetic gene clusters, and vast chemical diversity of natural products that they encode, in Photorhabdus and XenorhabDus, bacteria that interact with hosts as symbionts and entomopathogens.
Journal ArticleDOI
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing
Edna Bode,Antje K. Heinrich,Merle Hirschmann,Desalegne Abebew,Yan-Ni Shi,Tien Duy Vo,Frank Wesche,Yi-Ming Shi,Peter Grün,Svenja Simonyi,Nadine Keller,Yvonne Engel,Sebastian L Wenski,Reuel Bennet,Sophie Beyer,Iris Bischoff,Anthony Buaya,Sophie C. Brandt,Ibrahim Cakmak,Harun Cimen,Simone Eckstein,Denia Frank,Robert Fürst,Martin Gand,Gerd Geisslinger,Selcuk Hazir,Marina Henke,Ralf Heermann,Virginie Lecaudey,Wilhelm Schäfer,Susanne Schiffmann,Anja Schüffler,Rebecca Schwenk,Marisa Skaljac,Eckhard Thines,Marco Thines,Thomas Ulshöfer,Andreas Vilcinskas,Thomas A. Wichelhaus,Helge B. Bode +39 more
TL;DR: This easyPACId approach (easy Promoter Activated Compound Identification) facilitates NP identification due to low interference from other NPs and allows direct bioactivity testing of supernatants containing secreted NPs, without laborious purification.
Journal ArticleDOI
Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.
Marek Wanior,Marek Wanior,Franziska Preuss,Franziska Preuss,Xiaomin Ni,Xiaomin Ni,Andreas Krämer,Andreas Krämer,Sebastian Mathea,Sebastian Mathea,Tamara Göbel,David Heidenreich,David Heidenreich,Svenja Simonyi,Astrid S. Kahnt,Andreas C. Joerger,Andreas C. Joerger,Stefan Knapp +17 more
TL;DR: Targeted SWI/SNF bromodomain inhibition blocked the expression of key genes during adipogenesis, including the transcription factors PPARγ and C/EBPα, and impaired the differentiation of 3T3-L1 murine fibroblasts into adipocytes.
Posted ContentDOI
Focused natural product elucidation by prioritizing high-throughput metabolomic studies with machine learning
Nicholas J. Tobias,César Parra-Rojas,Yan-Ni Shi,Yi-Ming Shi,Svenja Simonyi,Aunchalee Thanwisai,Apichat Vitta,Narisara Chantratita,Esteban A. Hernandez-Vargas,Helge B. Bode +9 more
TL;DR: A comprehensive metabolic screening using HPLC-MS data associated with a 114-strain collection from across Thailand and utilizing machine learning in order to rank the importance of individual metabolites in determining all given metadata, leading to the identification of previously unknown compounds.
Journal ArticleDOI
Cyclo(tetrahydroxybutyrate) production is sufficient to distinguish between Xenorhabdus and Photorhabdus isolates in Thailand.
Nicholas J. Tobias,César Parra-Rojas,Yan-Ni Shi,Yi-Ming Shi,Svenja Simonyi,Aunchalee Thanwisai,Apichat Vitta,Narisara Chantratita,Esteban A. Hernandez-Vargas,Helge B. Bode +9 more
TL;DR: A comprehensive metabolic screening using HPLC-MS data associated with a 114-strain collection across Thailand and utilizing machine learning in order to rank the importance of individual metabolites in determining all given metadata, leading to the identification of previously unknown compounds.