Takashi Saito

TL;DR: In this article, an active bentonite-formed material is used to provide litter sand for a pet, which is characterized by having a composition; Al 2 O 3 /SiO 2 = 0.08-0.13, and Na 2 O/SiO2 =0.0025 −0.08 expressed by molar ratio based on oxide, and a paste prepared by drying the bentonite for 3 hr at 150°C and then being mixed with 1.0 ml water per 1 g shows a peak at 2θ=4-5° in an

TL;DR: This article showed that oral infection with Porphyromonas gingivalis (Pg), a keystone pathogen of periodontitis, worsened behavioral and cognitive impairment and accelerated amyloid beta accumulation in AD mice, thus unquestionably and significantly aggravating AD.

TL;DR: In this article, the effects of tooth loss on memory impairment and AD pathogenesis in AppNL-G-F mice were investigated, and they found that tooth loss induced glial activation, which in turn leads to the upregulation of the mRNA expression levels of the neuroinflammation cytokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β in the hippocampus.

TL;DR: In this article, the authors proposed a solution to provide a packaging container allowing a content to be refilled into a preserving container without spilling the content during refilling operation, and an funnel part used for the packaging container and the package.

TL;DR: T-cell activation is induced through the T CR microcluster (TCR-MC), which is generated by dynamically recruiting the TCR, kinases, and adaptors to trigger the full activation signal.