T
Takashi Saito
Researcher at Nagoya City University
Publications - 1220
Citations - 60014
Takashi Saito is an academic researcher from Nagoya City University. The author has contributed to research in topics: Medicine & MAGIC (telescope). The author has an hindex of 112, co-authored 1041 publications receiving 52937 citations. Previous affiliations of Takashi Saito include Mitsubishi Electric & Nippon Medical School.
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Journal ArticleDOI
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
Seung Yong Park,Kaoru Saijo,Takamune Takahashi,Masataka Osawa,Hisashi Areas,Nakami Hirayama,Keiko Miyake,Hiromitsu Nakauchi,Takuji Shirasawa,Takashi Saito +9 more
TL;DR: The crucial role of Jak3 is established in the development of lymphoid cells through the association with the common gamma chain of the cytokine receptors such as IL-2,IL-4, IL-7, Il-9, and IL-15.
Journal ArticleDOI
APP mouse models for Alzheimer's disease preclinical studies
Hiroki Sasaguri,Hiroki Sasaguri,Per Nilsson,Per Nilsson,Shoko Hashimoto,Kenichi Nagata,Takashi Saito,Takashi Saito,Bart De Strooper,Bart De Strooper,John Hardy,Robert Vassar,Bengt Winblad,Takaomi C. Saido +13 more
TL;DR: Different APP mouse models of AD are evaluated, the comparative strengths and limitations of each model are considered against the scientific and therapeutic goal of a prospective preclinical study, and recent studies using the second‐generation mice are reviewed.
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ScaleS: an optical clearing palette for biological imaging
Hiroshi Hama,Hiroyuki Hioki,Kana Namiki,Tetsushi Hoshida,Hiroshi Kurokawa,Fumiyoshi Ishidate,Takeshi Kaneko,Takumi Akagi,Takashi Saito,Takaomi C. Saido,Atsushi Miyawaki +10 more
TL;DR: ScaleS permitted optical reconstructions of aged and diseased brain in Alzheimer's disease models, including mapping of 3D networks of amyloid plaques, neurons and microglia, and multi-scale tracking of single plaques by successive fluorescence and electron microscopy.
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The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen
A. Poole,Jonathan M. Gibbins,Martin R Turner,M. van Vugt,J.G.J. van de Winkel,Takashi Saito,Victor L. J. Tybulewicz,Steve P. Watson +7 more
TL;DR: Observations provide the first direct evidence of an essential role for the immunoreceptor tyrosine‐based activation motif (ITAM) in signalling by a non‐immune receptor stimulus.
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Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ
Kirk D. C. Jensen,Xiaoqin Su,Sunny Shin,Luke Li,Sawsan Youssef,Sho Yamasaki,Lawrence Steinman,Takashi Saito,Richard M. Locksley,Mark M. Davis,Mark M. Davis,Nicole Baumgarth,Yueh-hsiu Chien +12 more
TL;DR: The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens, and thymic selection determines the effector fate of gammad delta T cells rather than constrains their antigen specificities.