T
Takashi Saito
Researcher at Nagoya City University
Publications - 1220
Citations - 60014
Takashi Saito is an academic researcher from Nagoya City University. The author has contributed to research in topics: Medicine & MAGIC (telescope). The author has an hindex of 112, co-authored 1041 publications receiving 52937 citations. Previous affiliations of Takashi Saito include Mitsubishi Electric & Nippon Medical School.
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Journal Article
Cd2 can mediate tcr/cd3-independent t cell activation
TL;DR: A clear resolution of the controversy concerning the requirement for surface CD3 expression in T cell activation through CD2 is provided and a possible role for CD2 in activation of TCR/CD3-negative cells is suggested.
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ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.
Tomonori Aikawa,Yingxue Ren,Yu Yamazaki,Masaya Tachibana,Madeleine R. Johnson,Casey T. Anderson,Yuka A. Martens,Marie Louise Holm,Yan W. Asmann,Takashi Saito,Takaomi C. Saido,Michael L. Fitzgerald,Guojun Bu,Takahisa Kanekiyo +13 more
TL;DR: It is shown that ABCA7 haplodeficiency compromises microglial responses by impairing CD14 expression on acute lipopolysaccharide stimulation in mouse models and contributes to AD pathogenesis by altering proper microglia responses to acute inflammatory challenges and during the development of amyloid pathology.
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The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology.
Hikari Tanaka,Kanoh Kondo,Xigui Chen,Hidenori Homma,Kazuhiko Tagawa,Aurelian Kerever,Shigeki Aoki,Takashi Saito,Takaomi C. Saido,Shin-ichi Muramatsu,Kyota Fujita,Hitoshi Okazawa +11 more
TL;DR: It is shown that phosphorylation of serine/arginine repetitive matrix 2 (SRRM2) at Ser1068, which is observed in the brains of early phase AD mouse models and postmortem end-stage AD patients, prevents its nuclear translocation by inhibiting interaction with T-complex protein subunit α.
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MAGIC TeV Gamma-Ray Observations of Markarian 421 during Multiwavelength Campaigns in 2006
Jelena Aleksić,L. A. Antonelli,P. Antoranz,Michael Backes,C. Baixeras,S. Balestra,Juan Abel Barrio,Denis Bastieri,J. Becerra González,Wlodek Bednarek,Andrei Berdyugin,K. Berger,Elisa Bernardini,Adrian Biland,R. K. Bock,R. K. Bock,Giacomo Bonnoli,Pol Bordas,D. Borla Tridon,Valentí Bosch-Ramon,D. Bose,Ilana M. Braun,Thomas Bretz,D. Britzger,M. Camara,E. Carmona,Alessandro Carosi,Pierre Colin,S. Commichau,Jose Luis Contreras,Juan Cortina,M. T. Costado,Stefano Covino,Francesco Dazzi,Francesco Dazzi,A. De Angelis,E. De Cea del Pozo,C. Delgado Mendez,R. de los Reyes,B. De Lotto,M. De Maria,F. De Sabata,M. Doert,Aaron Dominguez,D. Dominis Prester,Daniela Dorner,Michele Doro,D. Elsaesser,Manel Errando,Daniel Ferenc,M. V. Fonseca,Ll. Font,R. J. García López,Markus Garczarczyk,Markus Gaug,Nikola Godinovic,D. Hadasch,A. Herrero,D. Hildebrand,D. Höhne-Mönch,J. Hose,Dario Hrupec,C. C. Hsu,T. Jogler,Stefan Klepser,T. Krähenbühl,Daniel Kranich,A. La Barbera,A. Laille,E. Leonardo,Elina Lindfors,Saverio Lombardi,Francesco Longo,M. López,E. Lorenz,E. Lorenz,Pratik Majumdar,G. Maneva,Nijil Mankuzhiyil,Karl Mannheim,Laura Maraschi,Mosè Mariotti,M. I. Martínez,Daniel Mazin,Mario Meucci,Jose Miguel Miranda,R. Mirzoyan,Hiroko Miyamoto,Javier Moldon,Mariano Moles,Abelardo Moralejo,Daniel Nieto,Kari Nilsson,Jelena Ninkovic,Reiko Orito,Igor Oya,S. Paiano,Riccardo Paoletti,J. M. Paredes,S. Partini,M. Pasanen,D. Pascoli,Felicitas Pauss,R. G. Pegna,Miguel A. Pérez-Torres,Massimo Persic,Massimo Persic,L. Peruzzo,Francisco Prada,E. Prandini,N. Puchades,I. Puljak,Ignasi Reichardt,Wolfgang Rhode,Marc Ribó,J. Rico,J. Rico,M. Rissi,S. Rügamer,A. Saggion,Takashi Saito,M. Salvati,Miguel A. Sánchez-Conde,Konstancja Satalecka,V. Scalzotto,V. Scapin,C. Schultz,T. Schweizer,M. Shayduk,S. N. Shore,Agnieszka Sierpowska-Bartosik,A. Sillanpää,Julian Sitarek,Dorota Sobczyńska,Felix Spanier,S. Spiro,Antonio Stamerra,B. Steinke,J. C. Struebig,Tihomir Surić,L. O. Takalo,Fabrizio Tavecchio,Petar Temnikov,Tomislav Terzić,D. Tescaro,Masahiro Teshima,Diego F. Torres,Diego F. Torres,H. Vankov,Robert Wagner,Victor Zabalza,Fabio Zandanel,Roberta Zanin +152 more
TL;DR: The Major Atmospheric Gamma Imaging Cerenkov (MAGIC) telescope participated in three multi-wavelength (MWL) campaigns, observing the blazar Markarian (Mkn) 421 during the nights of 2006 April 28, 29, and 2006 June 14 as discussed by the authors.
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Implication of GnT-V in cancer metastasis: a glycomic approach for identification of a target protein and its unique function as an angiogenic cofactor.
TL;DR: The cloning of the UDP-GlcNAc α-mannoside β1-6-N -acetylglucosaminyltransferase (GnT-V) enzyme was carried out and Knock out mice developed by Dennis’s group confirmed that the gene is highly linked to cancer development.