Takashi Saito

TL;DR: It is demonstrated that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife, and it is shown that hyperspectral imaging can be used to quantify retinal Aβ, underscoring its potential as a biomarker for AD diagnosis and monitoring.

TL;DR: In this article , the authors found that endothelial APP expression would be markedly lower in rodents and subsequently generated mice that specifically expressed human WT APP (APP770) in endothelial cells (ECs).

TL;DR: It is expected that ERT may have prevented the manifestation of skeletal muscle involvement in this patient, and the efficacy of ERT is thought to depend on the extent of muscle damage at its commencement.

TL;DR: Hybrid photon detectors are one of the few low light level sensors that can provide an excellent single and multiple photoelectron amplitude resolution as discussed by the authors, and the recently developed hybrid photon detectors for the Major Atmospheric Gamma-Imaging Cherenkov (MAGIC) telescope project with an 18mmdiameter GaAsP photocathode (the Hamamatsu R9792U-40) have a peak quantum efficiency of more than 50% and a pulse width of ∼ 2.3 ns.

TL;DR: In this paper, the authors developed a new FRAP model aimed at long-term measurements to quantitatively determine the two distinct effects of the advection and chemical reaction, i.e., the different major sources of the change in fluorescence intensity.