Takashi Saito

TL;DR: A gene transfer strategy based on BBB‐crossing adeno‐associated virus (AAV)‐based vectors to deliver VHH directly into the central nervous system and demonstrates positive long‐term effects on amyloid load, neuroinflammation, synaptic function, and cognitive performance in the AppNL‐G‐F Alzheimer’s mouse model.

TL;DR: In this paper, the electronic structure of BaFeO3 was investigated by using HAXPES and XAS measurements and first principle studies, and the experimental and theoretical results indicated that the on-site Coulomb energy and the strong hybridization between Fe-3d and O-2p orbitals play a very important role of emergence of negative charge transfer.

TL;DR: In this article, the authors used a knock-in mouse model to overcome potential artifacts derived from transgenes, which accumulates Aβ plaques from 6 months and shows mild cognitive impairment at 18 months of age, without the overproduction of APP.

TL;DR: Oral PGI2, beraprost, appears to be an effective and possibly adequate substitute for intravenous vasodilators in pulmonary hypertension for both short- and long-term management.

TL;DR: It is suggested that AppNL-P-F/NL- P-F mice may be a useful model for evaluating Aβ oligomer-induced cognitive impairment in AD and will aid in exploring therapeutic targets for AD pathology.