T
Takashi Saito
Researcher at Nagoya City University
Publications - 1220
Citations - 60014
Takashi Saito is an academic researcher from Nagoya City University. The author has contributed to research in topics: Medicine & MAGIC (telescope). The author has an hindex of 112, co-authored 1041 publications receiving 52937 citations. Previous affiliations of Takashi Saito include Mitsubishi Electric & Nippon Medical School.
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Journal ArticleDOI
Tyrosine Phosphorylation Controls Internalization of CTLA-4 by Regulating Its Interaction with Clathrin-Associated Adaptor Complex AP-2
Tooru Shiratori,Shoichiro Miyatake,Hiroshi Ohno,Chiaki Nakaseko,Kaichi Isono,Juan S. Bonifacino,Takashi Saito +6 more
TL;DR: It is demonstrated that CTLA-4 interacts with the mu2 subunit of the plasma membrane-associated adaptor complex, AP-2, through the same motif involved in the interaction with Syp, except that the interactionWith mu2 requires unphosphorylated tyrosine.
Journal ArticleDOI
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.
Takashi Saito,Nobuhisa Iwata,Satoshi Tsubuki,Yoshie Takaki,Jiro Takano,Shu-Ming Huang,Takahiro Suemoto,Makoto Higuchi,Takaomi C. Saido +8 more
TL;DR: The results indicate that the aging-induced downregulation of somatostatin expression may be a trigger for Aβ accumulation leading to late-onset sporadic Alzheimer disease, and suggest that som atostatin receptors may be pharmacological-target candidates for prevention and treatment of Alzheimer disease.
Journal ArticleDOI
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.
Hiromitsu Hara,Chitose Ishihara,Arata Takeuchi,Takayuki Imanishi,Liquan Xue,Stephan W. Morris,Masanori Inui,Toshiyuki Takai,Akira Shibuya,Shinobu Saijo,Yoichiro Iwakura,Naohito Ohno,Haruhiko Koseki,Hiroki Yoshida,Josef M. Penninger,Takashi Saito +15 more
TL;DR: Deletion of the gene encoding the Bcl-10 adaptor–binding partner CARD9 resulted in impaired myeloid cell activation of NF-κB signaling by several ITAM-associated receptors, and CARD9 was required for Toll-like receptor–induced activation of dendritic cells through the activation of mitogen-activated protein kinases.
Journal ArticleDOI
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.
Tadashi Yokosuka,Wakana Kobayashi,Kumiko Sakata-Sogawa,Masako Takamatsu,Akiko Hashimoto-Tane,Michael L. Dustin,Makio Tokunaga,Takashi Saito +7 more
TL;DR: The accumulation of MCs at the cSMAC was accompanied by the segregation of CD28 from the TCR, which resulted in the translocation of both CD28 and PKCtheta to a spatially unique subregion of c SMAC.
Journal ArticleDOI
FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection.
Andreea Ioan-Facsinay,S. de Kimpe,Sandra M. M. Hellwig,P.L.E.M. van Lent,Frans M. A. Hofhuis,H.H van Ojik,Christine Sedlik,S.A da Silveira,J. Gerber,Y.F de Jong,R. Roozendaal,Lucien A. Aarden,W.B. van den Berg,Takashi Saito,David M. Mosser,Sebastian Amigorena,Shozo Izui,G-J B van Ommen,M van Vugt,J.G.J. van de Winkel,J.G.J. van de Winkel,J. S. Verbeek +21 more
TL;DR: It is concluded that FcgammaRI contributes substantially to a variety of IgG2a-IC-dependent immune functions and immunopathological responses.