A
Arman Jahangiri
Researcher at University of California, San Francisco
Publications - 58
Citations - 3261
Arman Jahangiri is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Tumor microenvironment & Angiogenesis. The author has an hindex of 25, co-authored 56 publications receiving 2506 citations. Previous affiliations of Arman Jahangiri include University of California & Emory University Hospital.
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Journal ArticleDOI
Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma
Yu-Long Hu,Michael DeLay,Arman Jahangiri,Annette M. Molinaro,Samuel D. Rose,W. Shawn Carbonell,Manish K. Aghi +6 more
TL;DR: The hypothesis that hypoxia caused by antiangiogenic therapy induces tumor cell autophagy as a cytoprotective adaptive response, thereby promoting treatment resistance is explored, and a novel mechanism of resistance to antiangIogenic therapy in which Hypoxia-mediatedautophagy promotes tumor cell survival is elucidated.
Journal ArticleDOI
Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma.
Annette M. Molinaro,Shawn L. Hervey-Jumper,Ramin A. Morshed,Jacob S. Young,Seunggu J. Han,Pranathi Chunduru,Yalan Zhang,Joanna J. Phillips,Anny Shai,Marisa Lafontaine,Jason C. Crane,Ankush Chandra,Patrick M. Flanigan,Arman Jahangiri,Gino Cioffi,Quinn T. Ostrom,John E. Anderson,John E. Anderson,Chaitra Badve,Chaitra Badve,Jill S. Barnholtz-Sloan,Jill S. Barnholtz-Sloan,Andrew E. Sloan,Andrew E. Sloan,Bradley J. Erickson,Paul A. Decker,Matthew L. Kosel,Daniel H. Lachance,Jeanette E. Eckel-Passow,Robert B. Jenkins,Javier Villanueva-Meyer,Terri Rice,Margaret Wrensch,John K. Wiencke,Nancy Ann Oberheim Bush,Jennie Taylor,Nicholas Butowski,Michael D. Prados,Jennifer Clarke,Susan M. Chang,Edward F. Chang,Manish K. Aghi,Philip V. Theodosopoulos,Michael W. McDermott,Mitchel S. Berger +44 more
TL;DR: An association between maximal resection of CE tumor and OS in patients with glioblastoma is confirmed across all subgroups and was associated with longer OS in younger patients, regardless of IDH status, and among patients with IDH-wild-type gliOBlastoma regardless of the methylation status of the promoter region of the DNA repair enzyme O6-methylguanine-DNA methyltransferase.
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Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis
Eric M. Thompson,Eric M. Thompson,Thomas Hielscher,Eric Bouffet,Marc Remke,Betty Luu,Sridharan Gururangan,Roger E. McLendon,Darell D. Bigner,Eric S. Lipp,Sébastien Perreault,Yoon Jae Cho,Gerald A. Grant,Gerald A. Grant,Seung-Ki Kim,Ji Yeoun Lee,Amulya A. Nageswara Rao,Caterina Giannini,Kay Ka Wai Li,Ho Keung Ng,Yu Yao,Toshihiro Kumabe,Teiji Tominaga,Wiesława Grajkowska,Marta Perek-Polnik,David C.Y. Low,Wan Tew Seow,Kenneth Tou En Chang,Jaume Mora,Ian F. Pollack,Ronald L. Hamilton,Sarah Leary,Andrew S. Moore,Andrew S. Moore,Wendy J. Ingram,Andrew R. Hallahan,Andrew R. Hallahan,Anne Jouvet,Michelle Fèvre-Montange,Alexandre Vasiljevic,Cécile Faure-Conter,Tomoko Shofuda,Naoki Kagawa,Naoya Hashimoto,Nada Jabado,Alexander G. Weil,Tenzin Gayden,Takafumi Wataya,Tarek Shalaby,Michael A. Grotzer,Karel Zitterbart,Jaroslav Sterba,Leos Kren,Tibor Hortobágyi,Almos Klekner,Bognár László,Tímea Pócza,Peter Hauser,Ulrich Schüller,Shin Jung,Woo Youl Jang,Pim J. French,Johan M. Kros,Marie Lise C. van Veelen,Luca Massimi,Jeffrey R. Leonard,Joshua B. Rubin,Rajeev Vibhakar,Lola B. Chambless,Michael K. Cooper,Reid C. Thompson,Claudia C. Faria,Alice Carvalho,Sofia Nunes,José Pimentel,Xing Fan,Karin M. Muraszko,Enrique López-Aguilar,David Lyden,Livia Garzia,David Shih,Noriyuki Kijima,Christian Schneider,Jennifer Adamski,Paul A. Northcott,Marcel Kool,David T.W. Jones,Jennifer A. Chan,Ana Nikolic,Maria Luisa Garrè,Erwin G. Van Meir,Satoru Osuka,Jeffrey J. Olson,Arman Jahangiri,Brandyn A. Castro,Nalin Gupta,William A. Weiss,Iska Moxon-Emre,Donald J. Mabbott,Alvaro Lassaletta,Cynthia Hawkins,Uri Tabori,James M. Drake,Abhaya V. Kulkarni,Peter B. Dirks,James T. Rutka,Andrey Korshunov,Stefan M. Pfister,Stefan M. Pfister,Roger J. Packer,Vijay Ramaswamy,Michael D. Taylor +111 more
TL;DR: A re-evaluation of the long-term implications of intensified craniospinal irradiation in children with small residual portions of medulloblastoma is suggested as the marked benefit of EOR in the overall cohort was greatly attenuated after including molecular subgroup in the multivariable analysis.
Journal ArticleDOI
Gene Expression Profile Identifies Tyrosine Kinase c-Met as a Targetable Mediator of Antiangiogenic Therapy Resistance
Arman Jahangiri,Michael De Lay,Liane M. Miller,W. Shawn Carbonell,Yu-Long Hu,Kan Lu,Maxwell W. Tom,Jesse Paquette,Taku Tokuyasu,Sean Tsao,Roxanne Marshall,Arie Perry,Kirsten Bjorgan,Myriam M. Chaumeil,Sabrina M. Ronen,Gabriele Bergers,Manish K. Aghi +16 more
TL;DR: Findings support the role of c-Met in survival in hypoxia and invasion, features associated with antiangiogenic therapy resistance, and growth and therapeutic resistance of xenografts resistant to antiangIogenic therapy.
Journal ArticleDOI
Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy.
TL;DR: Efforts to understand and modulate the autophagy pathway will be crucial to maximize the full therapeutic potential of cancer therapies that are currently hindered by tumor cell Autophagy as a resistance mechanism.