Teresa R. Ward

TL;DR: It is shown that previously known and new genes are necessary for optimal growth under six well-studied conditions: high salt, sorbitol, galactose, pH 8, minimal medium and nystatin treatment, and less than 7% of genes that exhibit a significant increase in messenger RNA expression are also required for optimal Growth in four of the tested conditions.

TL;DR: A total of 6925 Saccharomyces cerevisiae strains were constructed, by a high-throughput strategy, each with a precise deletion of one of 2026 ORFs (more than one-third of the ORFs in the genome), finding that 17 percent were essential for viability in rich medium.

TL;DR: The general usefulness of expression profiles for nearly 300 Saccharomyces cerevisiae deletion mutants, obtained recently, is demonstrated, with implications for interpreting whole-genome expression data, particularly from cells known to suffer genomic instability, such as malignant or immortalized cells.

TL;DR: The results suggest that patients whose tumors overexpress AurKA due to amplification of 20q will more likely resist treatment with Kinesin-5 inhibitor, and that inactivation of AURKA may sensitize these patients to treatment.

TL;DR: In this paper, the LXR-Ligand Induced I (LXRLI1) gene expression profile was used to diagnose a disease or disorder involving LXR activity, screen for compounds that change the activity of LXR and to classify LXR ligands.