T
Tharick A. Pascoal
Researcher at McGill University
Publications - 166
Citations - 4113
Tharick A. Pascoal is an academic researcher from McGill University. The author has contributed to research in topics: Medicine & Dementia. The author has an hindex of 20, co-authored 90 publications receiving 1633 citations. Previous affiliations of Tharick A. Pascoal include Pontifícia Universidade Católica do Rio Grande do Sul & Douglas Mental Health University Institute.
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Journal ArticleDOI
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.
Thomas K. Karikari,Tharick A. Pascoal,Tharick A. Pascoal,Nicholas J. Ashton,Shorena Janelidze,Andrea Lessa Benedet,Juan Lantero Rodriguez,Mira Chamoun,Melissa Savard,Min Su Kang,Min Su Kang,Joseph Therriault,Michael Schöll,Gassan Massarweh,Jean-Paul Soucy,Kina Höglund,Kina Höglund,Gunnar Brinkmalm,Niklas Mattsson,Sebastian Palmqvist,Serge Gauthier,Erik Stomrud,Henrik Zetterberg,Henrik Zetterberg,Henrik Zetterberg,Oskar Hansson,Pedro Rosa-Neto,Pedro Rosa-Neto,Kaj Blennow,Kaj Blennow +29 more
TL;DR: Blood p-tau181 can predict tau and amyloid β pathologies, differentiate Alzheimer's disease from other neurodegenerative disorders, and identify Alzheimer's Disease across the clinical continuum.
Journal ArticleDOI
Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain
Kok Pin Ng,Tharick A. Pascoal,Sulantha Mathotaarachchi,Joseph Therriault,Min Su Kang,Monica Shin,Marie-Christine Guiot,Qi Guo,Ryuichi Harada,Robert A. Comley,Gassan Massarweh,Jean-Paul Soucy,Nobuyuki Okamura,Serge Gauthier,Pedro Rosa-Neto +14 more
TL;DR: The results indicate that the interpretation of 18F-THK5351 PET images, with respect to tau, is confounded by the high MAO-B availability across the entire brain.
Journal ArticleDOI
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology
Nicholas J. Ashton,Tharick A. Pascoal,Thomas K. Karikari,Andrea Lessa Benedet,Andrea Lessa Benedet,Juan Lantero-Rodriguez,Gunnar Brinkmalm,Anniina Snellman,Michael Schöll,Michael Schöll,Claire Troakes,Abdul Hye,Abdul Hye,Serge Gauthier,Eugeen Vanmechelen,Henrik Zetterberg,Pedro Rosa-Neto,Pedro Rosa-Neto,Pedro Rosa-Neto,Kaj Blennow,Kaj Blennow +20 more
TL;DR: In this paper, the authors developed an ultrasensitive Single Molecule Array (Simoa) for the quantification of plasma p-tau231 which was validated in four independent cohorts (n = 0.588) in different settings, including the full AD continuum and non-AD neurodegenerative disorders.
Journal ArticleDOI
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative.
Thomas K. Karikari,Andrea Lessa Benedet,Nicholas J. Ashton,Juan Lantero Rodriguez,Anniina Snellman,Anniina Snellman,Marc Suárez-Calvet,Paramita Saha-Chaudhuri,Firoza Z. Lussier,Hlin Kvartsberg,Hlin Kvartsberg,Alexis Moscoso Rial,Tharick A. Pascoal,Tharick A. Pascoal,Ulf Andreasson,Ulf Andreasson,Michael Schöll,Michael Schöll,Michael W. Weiner,Pedro Rosa-Neto,Pedro Rosa-Neto,John Q. Trojanowski,Leslie M. Shaw,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Alzheimer’s Disease Neuroimaging Initiative +26 more
TL;DR: This study adds significant weight to the growing body of evidence in the use of plasma p-tau181 as a non-invasive diagnostic and prognostic tool for AD, regardless of clinical stage, which would be of great benefit in clinical practice and a large cost-saving in clinical trial recruitment.
Journal ArticleDOI
Microglial activation and tau propagate jointly across Braak stages
Tharick A. Pascoal,Andrea Lessa Benedet,Nicholas J. Ashton,Nicholas J. Ashton,Nicholas J. Ashton,Min Su Kang,Min Su Kang,Joseph Therriault,Mira Chamoun,Melissa Savard,Firoza Z. Lussier,Cecile Tissot,Thomas K. Karikari,Julie Ottoy,Julie Ottoy,Sulantha Mathotaarachchi,Jenna Stevenson,Gassan Massarweh,Michael Schöll,Michael Schöll,Mony J. de Leon,Jean-Paul Soucy,Paul Edison,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Serge Gauthier,Pedro Rosa-Neto,Pedro Rosa-Neto +28 more
TL;DR: In this paper, the spatial propagation of microglial activation and tau accumulation colocalize in a Braak-like pattern in the living human brain, suggesting an interaction that determines disease progression.