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Thomas Westerling
Researcher at Harvard University
Publications - 14
Citations - 932
Thomas Westerling is an academic researcher from Harvard University. The author has contributed to research in topics: Estrogen receptor & Estrogen. The author has an hindex of 12, co-authored 14 publications receiving 735 citations. Previous affiliations of Thomas Westerling include Tufts Medical Center & Brigham and Women's Hospital.
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Journal ArticleDOI
Growth factor stimulation induces a distinct ERα cistrome underlying breast cancer endocrine resistance
Mathieu Lupien,Clifford A. Meyer,Shannon T. Bailey,Jérôme Eeckhoute,Jennifer Cook,Thomas Westerling,Xiaoyang Zhang,Jason S. Carroll,Daniel R. Rhodes,X. Shirley Liu,Myles Brown +10 more
TL;DR: It is shown that the EGF-induced ERα genomic targets, its cistromes, are distinct from those induced by estrogen in a process dependent on the transcription factor AP-1, and this provides a potential molecular explanation for the endocrine therapy resistance seen in ERα-positive breast cancers that overexpress ERBB2.
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Feedback Regulation of Transcriptional Termination by the Mammalian Circadian Clock PERIOD Complex
TL;DR: The transcriptional feedback mechanism at the heart of the mammalian circadian clock was explored, finding that mouse PER complexes included RNA helicases DDX5 and DHX9, active RNA polymerase II large subunit, Per and Cry pre-mRNAs, and SETX, a helicase that promotes transcriptional termination.
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Estrogen receptor prevents p53-dependent apoptosis in breast cancer
Shannon T. Bailey,Shannon T. Bailey,Hyunjin Shin,Thomas Westerling,Thomas Westerling,Xiaole Shirley Liu,Myles Brown,Myles Brown +7 more
TL;DR: This work has addressed the mechanism by which ER antagonizes the proapoptotic function of p53 and suggested an improved strategy for the treatment of ER+ breast cancer using antagonists that completely block ER action together with drugs that activate p53-mediated cell death.
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Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells
Luz E. Tavera-Mendoza,Thomas Westerling,Eric Libby,Andriy Marusyk,Laura Cato,Raymundo Cassani,Lisa A. Cameron,Scott B. Ficarro,Jarrod A. Marto,Jelena Klawitter,Myles Brown +10 more
TL;DR: It is revealed that vitamin D and its receptor regulate autophagy in both normal mammary epithelial cells and luminal BCs, and a potential mechanism underlying the link between vitamin D levels and BC risk is suggested.
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Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis
Jingwei Cheng,Donglim Esther Park,Christian Berrios,Elizabeth A. White,Reety Arora,Rosa Yoon,Timothy Branigan,Tengfei Xiao,Thomas Westerling,Thomas Westerling,Alexander J. Federation,Rhamy Zeid,Benjamin J. Strober,Selene K. Swanson,Laurence Florens,James E. Bradner,James E. Bradner,Myles Brown,Peter M. Howley,Megha Padi,Michael P. Washburn,Michael P. Washburn,James A. DeCaprio,James A. DeCaprio +23 more
TL;DR: It is demonstrated that ST can activate gene expression in a EP400 and MYCL dependent manner and this activity contributes to cellular transformation and generation of induced pluripotent stem cells.