T
Taichi Hara
Researcher at Gunma University
Publications - 32
Citations - 12826
Taichi Hara is an academic researcher from Gunma University. The author has contributed to research in topics: Autophagy & Ubiquitin ligase. The author has an hindex of 25, co-authored 31 publications receiving 11568 citations. Previous affiliations of Taichi Hara include Tokyo Medical and Dental University & University of Pennsylvania.
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Journal ArticleDOI
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara,Kenji Nakamura,Makoto Matsui,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Yohko Nakahara,Rika Suzuki-Migishima,Minesuke Yokoyama,Kenji Mishima,Ichiro Saito,Hideyuki Okano,Noboru Mizushima +12 more
TL;DR: The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.
Journal ArticleDOI
Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice
Masaaki Komatsu,Satoshi Waguri,Masato Koike,Yu-shin Sou,Yu-shin Sou,Takashi Ueno,Taichi Hara,Noboru Mizushima,Junichi Iwata,Junichi Iwata,Junji Ezaki,Shigeo Murata,Jun Hamazaki,Yasumasa Nishito,Shun-ichiro Iemura,Tohru Natsume,Toru Yanagawa,Junya Uwayama,Eiji Warabi,Hiroshi Yoshida,Tetsuro Ishii,Akira Kobayashi,Masayuki Yamamoto,Zhenyu Yue,Yasuo Uchiyama,Eiki Kominami,Keiji Tanaka +26 more
TL;DR: The findings highlight the unexpected role of homeostatic level of p62, which is regulated by autophagy, in controlling intracellular inclusion body formation, and indicate that the pathologic process associated with autophagic deficiency is cell-type specific.
Journal ArticleDOI
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
Nao Hosokawa,Taichi Hara,Takeshi Kaizuka,Chieko Kishi,Akito Takamura,Yutaka Miura,Shun-ichiro Iemura,Tohru Natsume,Kenji Takehana,Naoyuki Yamada,Jun-Lin Guan,Noriko Oshiro,Noriko Oshiro,Noboru Mizushima +13 more
TL;DR: A novel mammalian autophagy factor, Atg13, is reported, which forms a stable approximately 3-MDa protein complex with ULK1 and FIP200, and suggests that mTORC1 suppressesAutophagy through direct regulation of the approximately 3,MDa ULK 1-Atg13-FIP200 complex.
Journal ArticleDOI
Autophagy-deficient mice develop multiple liver tumors
Akito Takamura,Masaaki Komatsu,Taichi Hara,Ayako Sakamoto,Chieko Kishi,Satoshi Waguri,Yoshinobu Eishi,Okio Hino,Keiji Tanaka,Noboru Mizushima +9 more
TL;DR: The results suggest that autophagy is important for the suppression of spontaneous tumorigenesis through a cell-intrinsic mechanism, particularly in the liver, and that p62 accumulation contributes to tumor progression.
Journal ArticleDOI
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
Taichi Hara,Akito Takamura,Chieko Kishi,Shun-ichiro Iemura,Tohru Natsume,Jun-Lin Guan,Noboru Mizushima +6 more
TL;DR: The results suggest that FIP200 is a novel mammalian autophagy factor that functions together with ULKs, which regulates diverse cellular functions such as cell size, proliferation, and migration.