N
Noriko Oshiro
Researcher at Kobe University
Publications - 36
Citations - 8587
Noriko Oshiro is an academic researcher from Kobe University. The author has contributed to research in topics: Phosphorylation & P70-S6 Kinase 1. The author has an hindex of 29, co-authored 36 publications receiving 7990 citations. Previous affiliations of Noriko Oshiro include Nara Institute of Science and Technology & Harvard University.
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Journal ArticleDOI
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
Nao Hosokawa,Taichi Hara,Takeshi Kaizuka,Chieko Kishi,Akito Takamura,Yutaka Miura,Shun-ichiro Iemura,Tohru Natsume,Kenji Takehana,Naoyuki Yamada,Jun-Lin Guan,Noriko Oshiro,Noriko Oshiro,Noboru Mizushima +13 more
TL;DR: A novel mammalian autophagy factor, Atg13, is reported, which forms a stable approximately 3-MDa protein complex with ULK1 and FIP200, and suggests that mTORC1 suppressesAutophagy through direct regulation of the approximately 3,MDa ULK 1-Atg13-FIP200 complex.
Journal ArticleDOI
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Kenta Hara,Yoshiko Maruki,Xiaomeng Long,Ken-ichi Yoshino,Noriko Oshiro,Sujuti Hidayat,Chiharu Tokunaga,Joseph Avruch,Kazuyoshi Yonezawa +8 more
TL;DR: Raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo and yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR.
Journal ArticleDOI
The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif
Hiroki Nojima,Hiroki Nojima,Chiharu Tokunaga,Satoshi Eguchi,Noriko Oshiro,Sujuti Hidayat,Ken-ichi Yoshino,Kenta Hara,Noriaki Tanaka,Joseph Avruch,Kazuyoshi Yonezawa +10 more
TL;DR: Raptor appears to serve as an mTOR scaffold protein, the binding of which to the TOS motif of mTOR substrates is necessary for effective mTOR-catalyzed phosphorylation in vivo and perhaps for conferring their sensitivity to rapamycin and amino acid sufficiency.
Journal ArticleDOI
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells.
Mirei Murakami,Tomoko Ichisaka,Tomoko Ichisaka,Mitsuyo Maeda,Noriko Oshiro,Noriko Oshiro,Kenta Hara,Kenta Hara,Frank Edenhofer,Hiroshi Kiyama,Kazuyoshi Yonezawa,Kazuyoshi Yonezawa,Shinya Yamanaka,Shinya Yamanaka +13 more
TL;DR: Deletion of the C-terminal six amino acids of mTOR, which are essential for kinase activity, resulted in reduced cell size and proliferation arrest in embryonic stem cells, and showed that mTOR controls both cell Size and proliferation in early mouse embryos and embryonicstem cells.
Journal ArticleDOI
Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo
Yoji Kawano,Yuko Fukata,Noriko Oshiro,Mutsuki Amano,Toshikazu Nakamura,Masaaki Ito,Fumio Matsumura,Masaki Inagaki,Kozo Kaibuchi +8 more
TL;DR: Results indicate that MBS is phosphorylated by Rho-kinase downstream of Rho in vivo, and suggest that myosin phosphatase and Rho -kinase spatiotemporally regulate the phosphorylation state of RHo-kinases substrates including MLC and ERM family proteins in vivo in a cooperative manner.