K
K Ueki
Researcher at University of Tokyo
Publications - 14
Citations - 5696
K Ueki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Insulin receptor & Insulin receptor substrate. The author has an hindex of 10, co-authored 14 publications receiving 5446 citations.
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Journal ArticleDOI
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Toshimasa Yamauchi,Junji Kamon,Yasuhiko Minokoshi,Yoichi M. Ito,Hironori Waki,S. Uchida,Shigeo Yamashita,Mitsuhiko Noda,Shunbun Kita,K Ueki,Koji Eto,Y. Akanuma,Philippe Froguel,Fabienne Foufelle,Pascal Ferré,David Carling,Shigeko Kimura,Ryozo Nagai,Barbara B. Kahn,Takashi Kadowaki +19 more
TL;DR: It is shown that phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full- lengths Ad in the liver, indicating that stimulation of glucose utilization and fatty-acid oxidation by Ad occurs through activation of AMPK.
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Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase
Yasuo Terauchi,Yuki Tsuji,Shinobu Satoh,H. Minoura,Katsuhiko Murakami,Akira Okuno,Kouichi Inukai,Tomoichiro Asano,Yasushi Kaburagi,K Ueki,Hiromu Nakajima,Toshiaki Hanafusa,Yuji Matsuzawa,Hisahiko Sekihara,Yuxin Yin,Barrett Jc,Hideaki Oda,Takatoshi Ishikawa,Yasuo Akanuma,Issei Komuro,Misao Suzuki,Ken Ichi Yamamura,Tatsuhiko Kodama,Hidekazu Suzuki,Shigeo Koyasu,Shinichi Aizawa,Kazuyuki Tobe,Y. Fukui,Yoshio Yazaki,Takashi Kadowaki +29 more
TL;DR: This work provides the first direct evidence that PI3K and its regulatory subunit have a role in glucose homeostasis in vivo.
Journal ArticleDOI
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.
Toshimasa Yamauchi,Kazuyuki Tobe,Hiroyuki Tamemoto,K Ueki,Yasushi Kaburagi,Ritsuko Yamamoto-Honda,Yoshihiko Takahashi,Fumiaki Yoshizawa,Shinichi Aizawa,Yasuo Akanuma,N Sonenberg,Yoshio Yazaki,Takashi Kadowaki +12 more
TL;DR: IRS-1 plays central roles in two major biological actions of insulin in muscles, glucose transport and protein synthesis, and the degree of compensation for IRS-1 deficiency appears to be correlated with the amount of tyrosine-phosphorylated IRS-2 relative to that of IRS- 1 (in wild-type mice).
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Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro.
M Kojima,Ichiro Shiojima,Tsutomu Yamazaki,Issei Komuro,Z Zou,Yuepeng Wang,Takehiko Mizuno,K Ueki,Kazuyuki Tobe,Takashi Kadowaki +9 more
TL;DR: The results suggest that the renin-angiotensin system (RAS) is involved in the formation of left ventricular hypertrophy (LVH), and a crucial role of the cardiac RAS in the development of LVH produced by pressure overload.
Journal ArticleDOI
The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability.
Tomoyuki Tanaka,Mineo Kurokawa,K Ueki,Kozo Tanaka,Yoichi Imai,Kinuko Mitani,K Okazaki,Noriyuki Sagata,Yoshio Yazaki,Yoichi Shibata,Takashi Kadowaki,Hisamaru Hirai +11 more
TL;DR: The results showed that AML1 is phosphorylated in vivo on two serine residues within the proline-, serine-, and threonine-rich region, with dependence on the activation of extracellular signal-regulated kinase (ERK) and with interleukin-3 stimulation in a hematopoietic cell line.