T
Toshiaki Ohteki
Researcher at Tokyo Medical and Dental University
Publications - 101
Citations - 11925
Toshiaki Ohteki is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 44, co-authored 99 publications receiving 11150 citations. Previous affiliations of Toshiaki Ohteki include Keio University & Ontario Institute for Cancer Research.
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Journal ArticleDOI
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Toshimasa Yamauchi,Junji Kamon,Yusuke Ito,Atsushi Tsuchida,Takehiko Yokomizo,Takehiko Yokomizo,Shunbun Kita,Takuya Sugiyama,Makoto Miyagishi,Makoto Miyagishi,Kazuo Hara,Masaki Tsunoda,Koji Murakami,Toshiaki Ohteki,S. Uchida,Sato Takekawa,Hironori Waki,Nelson H. Tsuno,Yoichi Shibata,Yasuo Terauchi,Philippe Froguel,Kazuyuki Tobe,Shigeo Koyasu,Kazunari Taira,Kazunari Taira,Toshio Kitamura,Takao Shimizu,Takao Shimizu,Ryozo Nagai,Takashi Kadowaki +29 more
TL;DR: The cloning of complementary DNAs encoding adiponectin receptors 1 and 2 by expression cloning supports the conclusion that they serve as receptors for globular and full-length adiponECTin, and that they mediate increased AMP kinase and PPAR-α ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectionin.
Journal ArticleDOI
Identification of clonogenic common Flt3 + M-CSFR + plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow
Nobuyuki Onai,Aya Obata-Onai,Michael A. Schmid,Toshiaki Ohteki,David Jarrossay,Markus G. Manz +5 more
TL;DR: This work identifies highly cycling Lin−c-KitintFlt3+M-CSFR+ cells with a distinct gene-expression profile in mouse bone marrow that efficiently generated plasmacytoid and conventional DCs but no other lineages, which increased in number after in vivo injection of the cytokine Flt3 ligand.
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T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
Akira Suzuki,Manae Tsukio Yamaguchi,Toshiaki Ohteki,Takehiko Sasaki,Tsuneyasu Kaisho,Yuki Kimura,Ritsuko Yoshida,Andrew Wakeham,Tetsuya Higuchi,Manabu Fukumoto,Takeshi Tsubata,Pamela S. Ohashi,Shigeo Koyasu,Josef M. Penninger,Toru Nakano,Tak W. Mak +15 more
TL;DR: PTEN, a tumor suppressor gene, is essential for embryogenesis and an important regulator of T cell homeostasis and self-tolerance in Pten(flox/-) mice.
Journal ArticleDOI
Selection of the t cell repertoire
Eric Sebzda,Sanjeev Mariathasan,Toshiaki Ohteki,Russell G. Jones,Martin F. Bachmann,Pamela S. Ohashi +5 more
TL;DR: Interactions during thymocyte maturation that define the T cell repertoire are focused on, with an emphasis placed on current literature within this field.
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Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
Hiroyuki Tezuka,Yukiko Abe,Makoto Iwata,Hajime Takeuchi,Hiromichi Ishikawa,Masayuki Matsushita,Tetsuo Shiohara,Shizuo Akira,Toshiaki Ohteki +8 more
TL;DR: It is shown that IgA class-switch recombination (CSR) is impaired in inducible-nitric-oxide-synthase-deficient (iNOS-/-; gene also called Nos2) mice, and the presence of a naturally occurring TNF-α/iNos-producing dendritic-cell subset may explain the predominance of IgA production in the MALT, critical for gut homeostasis.