Journal ArticleDOI
Selection of the t cell repertoire
Eric Sebzda,Sanjeev Mariathasan,Toshiaki Ohteki,Russell G. Jones,Martin F. Bachmann,Pamela S. Ohashi +5 more
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TLDR
Interactions during thymocyte maturation that define the T cell repertoire are focused on, with an emphasis placed on current literature within this field.Abstract:
Advances in gene technology have allowed the manipulation of molecular interactions that shape the T cell repertoire. Although recognized as fundamental aspects of T lymphocyte development, only recently have the mechanisms governing positive and negative selection been examined at a molecular level. Positive selection refers to the active process of rescuing MHC-restricted thymocytes from programmed cell death. Negative selection refers to the deletion or inactivation of potentially autoreactive thymocytes. This review focuses on interactions during thymocyte maturation that define the T cell repertoire, with an emphasis placed on current literature within this field.read more
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CD95's deadly mission in the immune system
TL;DR: The role of CD95 (Apo-1/Fas)-mediated signalling in T-cell and B-cell development and during the course of an immune response and the understanding of the pathogenesis of diseases such as cancer, autoimmunity and AIDS is improved.
Journal ArticleDOI
MAP Kinases in the Immune Response
TL;DR: Recent progress in understanding the function and regulation of MAP kinase pathways in these phases of immune responses in mammalian species is summarized.
Journal ArticleDOI
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide.
Martha S. Jordan,Alina Boesteanu,Amy J. Reed,Andria L. Petrone,Andrea E. Holenbeck,Melissa A. Lerman,Ali Naji,Andrew J. Caton +7 more
TL;DR: It is shown that interactions with a single self-peptide can induce thymocytes that bear an autoreactive T cell receptor (TCR) to undergo selection to become CD4+CD25+ regulatory T cells.
Journal ArticleDOI
Positive and Negative Selection of T Cells
TL;DR: The current state of the field regarding the natural ligands and molecular factors required for positive and negative selection are summarized and a model for how these disparate outcomes can be signaled via the same receptor is discussed.
Journal ArticleDOI
The immune system. First of two parts.
Peter J. Delves,Ivan M. Roitt +1 more
TL;DR: The immune system is an organization of cells and molecules with specialized roles in defending against infection as discussed by the authors, and there are two fundamentally different types of responses to invading microbes: innate and adaptive.
References
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Journal ArticleDOI
The Fas Death Factor
Shigekazu Nagata,Pierre Golstein +1 more
TL;DR: Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells.
Journal ArticleDOI
T cell receptor antagonist peptides induce positive selection
Kristin A. Hogquist,Stephen C. Jameson,William R. Heath,Jane L Howard,Michael J. Bevan,Francis R. Carbone +5 more
TL;DR: Results show that the process of positive selection is exquisitely peptide specific and sensitive to extremely low ligand density and support the notion that low efficacy ligands mediate positive selection.
Journal ArticleDOI
T cell tolerance by clonal elimination in the thymus
TL;DR: The results show that in normal animals tolerance to self-MHC is due to clonal elimination rather than suppression, and indicate that tolerance induction may occur in the thymus at the time immature thymocytes are selected to move into the mature thymocyte pool.
Journal ArticleDOI
Signal transduction by lymphocyte antigen receptors
Arthur Weiss,Dan R. Littman +1 more
TL;DR: Insight gained from studies of the signaling pathways downstream of TCR and BCR stimulation is likely to contribute significantly to future understanding of mechanisms responsible for lymphocyte differentiation and for the discrimination of self from nonself in developing and mature cells.
Journal ArticleDOI
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.
TL;DR: Evidence is presented here that the interaction of cytotoxic T cells with other somatic cells budding4–5 lymphocytic choriomeningitis (LCM) virus is similarly restricted.
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