V
Vaishnav Krishnan
Researcher at Baylor College of Medicine
Publications - 67
Citations - 13434
Vaishnav Krishnan is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Social defeat & Medicine. The author has an hindex of 31, co-authored 54 publications receiving 11926 citations. Previous affiliations of Vaishnav Krishnan include Beth Israel Deaconess Medical Center & University of Texas at Dallas.
Papers
More filters
Journal ArticleDOI
The molecular neurobiology of depression
TL;DR: Recent studies combining behavioural, molecular and electrophysiological techniques reveal that certain aspects of depression result from maladaptive stress-induced neuroplastic changes in specific neural circuits and show that understanding the mechanisms of resilience to stress offers a crucial new dimension for the development of fundamentally novel antidepressant treatments.
Journal ArticleDOI
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Olivier Berton,Colleen A. McClung,Ralph J. DiLeone,Vaishnav Krishnan,William Renthal,Scott J. Russo,Danielle Graham,Nadia M. Tsankova,Carlos A. Bolaños,Maribel Rios,Lisa M. Monteggia,David W. Self,Eric J. Nestler,Eric J. Nestler +13 more
TL;DR: It is shown that viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor is required for the development of experience-dependent social aversion in mice experiencing repeated aggression.
Journal ArticleDOI
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Vaishnav Krishnan,Ming-Hu Han,Danielle Graham,Olivier Berton,William Renthal,Scott J. Russo,Quincey LaPlant,Ami Graham,Michael Lutter,Diane C. Lagace,Subroto Ghose,Robin Reister,Paul Tannous,Thomas A. Green,Rachael L. Neve,Sumana Chakravarty,Arvind Kumar,Amelia J. Eisch,David W. Self,Francis S. Lee,Carol A. Tamminga,Donald C. Cooper,Howard K. Gershenfeld,Eric J. Nestler +23 more
TL;DR: It is shown that molecular recapitulations of three prototypical adaptations associated with the unsusceptible phenotype are each sufficient to promote resistant behavior and validate a multidisciplinary approach to examine the neurobiological mechanisms of variations in stress resistance.
Journal ArticleDOI
Mania-like behavior induced by disruption of CLOCK.
Kole T. Roybal,David Theobold,Ami Graham,Jennifer A. DiNieri,Scott J. Russo,Vaishnav Krishnan,Sumana Chakravarty,Joseph Peevey,Nathan Oehrlein,Shari G. Birnbaum,Martha Hotz Vitaterna,Paul Orsulak,Joseph S. Takahashi,Eric J. Nestler,William A. Carlezon,Colleen A. McClung +15 more
TL;DR: It is shown that mice carrying a mutation in the Clock gene display an overall behavioral profile that is strikingly similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, lower anxiety, and an increase in the reward value for cocaine, sucrose, and medial forebrain bundle stimulation.
Journal ArticleDOI
Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli
William Renthal,Ian Maze,Vaishnav Krishnan,Herbert E. Covington,Guanghua Xiao,Arvind Kumar,Scott J. Russo,Ami Graham,Nadia M. Tsankova,Tod E. Kippin,Kerry A. Kerstetter,Rachael L. Neve,Stephen J. Haggarty,Timothy A. McKinsey,Rhonda S Bassel-Duby,Eric N. Olson,Eric J. Nestler +16 more
TL;DR: It is suggested that proper balance of histone acetylation is a crucial factor in the saliency of a given stimulus and that disruption of this balance is involved in the transition from an acute adaptive response to a chronic psychiatric illness.