Vamsi K. Mootha

TL;DR: This study evaluated whether acute exposure to GRAS levels of sodium benzoate alters insulin and glucose homeostasis through a randomized, controlled, cross-over study of 14 overweight subjects, and found no statistically significant effect of an acute oral exposure to sodium Benzoate on glucoseHomeostasis.

TL;DR: It is demonstrated that one such factor, FASTKD4, modulates the half-lives of a subset of mt-mRNAs and associates with mtRNAs in vivo, and may be useful for diagnosing and deciphering the pathogenesis of mtDNA disorders.

TL;DR: A combined homozygosity mapping and bioinformatics approach in a consanguineous Iranian-Jewish pedigree led to the identification of a homozygous mutation in FOXRED1 in a child who presented with infantile-onset encephalomyopathy, and this FAD-dependent oxidoreductase, which has never previously been associated with human disease, is now shown to be a complex I-specific molecular chaperone.

TL;DR: A simple spectroscopic method for determining the cytochrome c oxidase, cy tochrome a, a3, content in tissue and mitochondria samples independent of myoglobin or blood contamination is described.

TL;DR: In this paper, the authors show that SARS-CoV-2 remodels host folate and one-carbon metabolism at the post-transcriptional level to support de novo purine synthesis, bypassing viral shutoff of host translation.