V
Vamsi K. Mootha
Researcher at Broad Institute
Publications - 243
Citations - 90559
Vamsi K. Mootha is an academic researcher from Broad Institute. The author has contributed to research in topics: Mitochondrion & Mitochondrial DNA. The author has an hindex of 85, co-authored 227 publications receiving 73860 citations. Previous affiliations of Vamsi K. Mootha include Harvard University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex
Yasemin Sancak,Andrew L. Markhard,Toshimori Kitami,Toshimori Kitami,Erika Kovács-Bogdán,Kimberli J. Kamer,Namrata D. Udeshi,Steven A. Carr,Dipayan Chaudhuri,Dipayan Chaudhuri,David E. Clapham,Andrew A. Li,Sarah E. Calvo,Sarah E. Calvo,Olga Goldberger,Vamsi K. Mootha,Vamsi K. Mootha +16 more
TL;DR: Sancak et al. complete the molecular characterization of the mitochondrial calcium uniporter (MCU), the multicomponent channel that allows concentration of calcium within the organelle, and identify a small protein termed “essential MCU regulator”—or EMRE—which was required for calcium transport activity of the fully assembled uniporters.
Journal ArticleDOI
MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations.
Sneha Rath,Sneha Rath,Rohit Sharma,Rohit Sharma,Rahul Gupta,Rahul Gupta,Tslil Ast,Tslil Ast,Connie Chan,Connie Chan,Timothy J. Durham,Timothy J. Durham,Russell P. Goodman,Russell P. Goodman,Zenon Grabarek,Zenon Grabarek,Mary E. Haas,Mary E. Haas,Wendy H. W. Hung,Wendy H. W. Hung,Pallavi R. Joshi,Pallavi R. Joshi,Alexis A. Jourdain,Alexis A. Jourdain,Sharon H. Kim,Sharon H. Kim,Anna V. Kotrys,Anna V. Kotrys,Stephanie S Lam,Stephanie S Lam,Jason G. McCoy,Jason G. McCoy,Joshua D. Meisel,Joshua D. Meisel,Maria Miranda,Maria Miranda,Apekshya Panda,Apekshya Panda,Anupam Patgiri,Anupam Patgiri,Robert S. Rogers,Robert S. Rogers,Shayan Sadre,Shayan Sadre,Hardik Shah,Hardik Shah,Owen S. Skinner,Owen S. Skinner,Tsz-Leung To,Tsz-Leung To,Melissa A. Walker,Melissa A. Walker,Hong Wang,Hong Wang,Patrick S. Ward,Patrick S. Ward,Jordan Wengrod,Jordan Wengrod,Chen-Ching Yuan,Chen-Ching Yuan,Sarah E. Calvo,Sarah E. Calvo,Vamsi K. Mootha,Vamsi K. Mootha +63 more
TL;DR: MitoCarta3.0, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome, is introduced and includes manually curated annotations of sub-mitochondrial localization and MitoPathway annotations, spanning seven broad functional categories relevant to mitochondria.
Journal ArticleDOI
The mitochondrial proteome and human disease.
Sarah E. Calvo,Vamsi K. Mootha +1 more
TL;DR: How the mitochondrial proteome is being used to discover the genetic basis of respiratory chain disorders as well as to expand the definition of mitochondrial disease are discussed.
Journal ArticleDOI
How many human proteoforms are there
Ruedi Aebersold,Jeffrey N. Agar,I. Jonathan Amster,Mark S. Baker,Carolyn R. Bertozzi,Emily S. Boja,Catherine E. Costello,Benjamin F. Cravatt,Catherine Fenselau,Benjamin A. Garcia,Ying Ge,Jeremy Gunawardena,Ronald C. Hendrickson,Paul J. Hergenrother,Christian G. Huber,Alexander R. Ivanov,Ole N. Jensen,Michael C. Jewett,Neil L. Kelleher,Laura L. Kiessling,Nevan J. Krogan,Martin R. Larsen,Joseph A. Loo,Rachel R. Ogorzalek Loo,Emma Lundberg,Emma Lundberg,Michael J. MacCoss,Parag Mallick,Vamsi K. Mootha,Milan Mrksich,Tom W. Muir,Steven M. Patrie,James J. Pesavento,Sharon J. Pitteri,Henry Rodriguez,Alan Saghatelian,Wendy Sandoval,Hartmut Schlüter,Salvatore Sechi,Sarah A. Slavoff,Lloyd M. Smith,Michael Snyder,Paul M. Thomas,Mathias Uhlén,Jennifer E. Van Eyk,Marc Vidal,David R. Walt,Forest M. White,Evan R. Williams,Therese Wohlschlager,Vicki H. Wysocki,Nathan A. Yates,Nicolas L. Young,Bing Zhang +53 more
TL;DR: This work frames central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today, and uses this framework to assess existing data and ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?"
Journal ArticleDOI
Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits
Ayellet V. Segrè,Magic Investigators,Leif Groop,Vamsi K. Mootha,Mark J. Daly,Mark J. Daly,David Altshuler +6 more
TL;DR: The results suggest that common variants affecting nuclear-encoded mitochondrial genes have at most a small genetic contribution to T2D susceptibility.