V
Vamsi K. Mootha
Researcher at Broad Institute
Publications - 243
Citations - 90559
Vamsi K. Mootha is an academic researcher from Broad Institute. The author has contributed to research in topics: Mitochondrion & Mitochondrial DNA. The author has an hindex of 85, co-authored 227 publications receiving 73860 citations. Previous affiliations of Vamsi K. Mootha include Harvard University & Beth Israel Deaconess Medical Center.
Papers
More filters
Patent
Glycine, mitochondrial one-carbon metabolism, and cancer
TL;DR: In this article, the authors proposed a method for treatment, diagnosis, and prognosis of cancer patients, generally comprising determining levels of glycine metabolism or a mitochondrial 1-carbon (1-C) pathway enzyme.
Journal ArticleDOI
Genetic Determinants of Venetoclax Resistance in Lymphoid Malignancies
Romain Guieze,Vivian M. Liu,Daniel Rosebrock,Alexis Jourdain,María Hernández-Sánchez,Aina Zurita Martinez,Sun Jing,Kaitlyn Baranowski,Philip A. Thompson,Heo Jin-Mi,Zacchary Cartun,Ozan Aygün,Giulia Notarangelo,Dimitri Livitz,Shuqiang Li,Matthew S. Davids,Jennifer R. Brown,William G. Wierda,Anthony Letai,Donna Neuberg,Wade Harper,Steven A. Carr,Federica Piccioni,Christopher J. Ott,Ignaty Leshchiner,Cory M. Johannessen,John G. Doench,Vamsi K. Mootha,Gad Getz,Catherine J. Wu +29 more
TL;DR: RNA-seq and spectrometry-based proteomics revealed coordinated dysregulation of transcripts and proteins in the resistant line originating from genes critical to cellular metabolism, cell cycle, B-cell biology and autophagy, and exposure of ID3 knockout lines to mETC inhibitors overcame resistance to venetoclax.
Journal ArticleDOI
MICU1 Serves as a Ca2+-Controlled Gatekeeper for the Mitochondrial Ca2+ Uniporter
György Csordás,Tünde Golenár,Erin L. Seifert,Fabiana Perocchi,Vamsi K. Mootha,György Hajnózky +5 more
TL;DR: It is proposed that the MICU1, through its EF-hands, controls the [Ca2+] set-point for MCU channel closure, which helps mitochondria to respond to physiological [Ca 2+] oscillations and provides some protection from Ca2+ overloading.
Peer ReviewDOI
Author response: Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell
Eran Mick,Eran Mick,Eran Mick,Denis V. Titov,Denis V. Titov,Denis V. Titov,Owen S. Skinner,Owen S. Skinner,Owen S. Skinner,Rohit Sharma,Rohit Sharma,Rohit Sharma,Alexis A. Jourdain,Alexis A. Jourdain,Alexis A. Jourdain,Vamsi K. Mootha,Vamsi K. Mootha,Vamsi K. Mootha +17 more