V
Vamsi K. Mootha
Researcher at Broad Institute
Publications - 243
Citations - 90559
Vamsi K. Mootha is an academic researcher from Broad Institute. The author has contributed to research in topics: Mitochondrion & Mitochondrial DNA. The author has an hindex of 85, co-authored 227 publications receiving 73860 citations. Previous affiliations of Vamsi K. Mootha include Harvard University & Beth Israel Deaconess Medical Center.
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Propranolol and the risk of hospitalized myopathy: translating chemical genomics findings into population-level hypotheses.
TL;DR: Propranolol may be associated with a 45% increased risk of hospitalized myopathy in the elderly and this study illustrates how results from in vitro chemical screens can be translated into hypotheses about drug toxicity at the population level.
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Author Correction: Cryo-EM structure of a fungal mitochondrial calcium uniporter
Nam X. Nguyen,Jean Paul Armache,Changkeun Lee,Changkeun Lee,Yi Yang,Weizhong Zeng,Vamsi K. Mootha,Yifan Cheng,Xiao Chen Bai,Youxing Jiang +9 more
TL;DR: In this Article, ref. 15 has been replaced and references 32 to 50 have been renumbered online.
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Bayesian hidden Markov tree models for clustering genes with shared evolutionary history
TL;DR: Clustering by Inferred Models of Evolution (CLIME 1.0) as mentioned in this paper employs a mixture of tree-structured hidden Markov models for gene evolution process, and a Bayesian model-based clustering algorithm to detect gene modules with shared evolutionary histories (termed evolutionary conserved modules, or ECMs).
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Neutral Carrier-Based “Ca2+-Selective” Microelectrodes for the Measurement of Tetraphenylphosphonium
TL;DR: It is argued that the ETH 1001 microelectrode can be used as a commercially available TPP+ electrode and illustrated by making membrane potential recordings in respiring mitochondria.
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Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis
Jarred W. Rensvold,Shao En Ong,Athavi Jeevananthan,Steven A. Carr,Vamsi K. Mootha,David J. Pagliarini +5 more
TL;DR: This work reveals that cellular iron is a key regulator of mitochondrial biogenesis, and provides quantitative data sets that can be leveraged to explore posttranscriptional and posttranslational processes that are essential for mitochondrial adaptation.