Showing papers in "American Heart Journal in 2010"

TL;DR: The ROCKET AF study will determine the efficacy and safety of rivaroxaban as an alternative to warfarin for the prevention of thromboembolism in patients with AF.

TL;DR: In this paper, a phase 3 comparison of the novel oral factor Xa inhibitor edoxaban to warfarin for the prevention of thromboembolism in patients with atrial fibrillation was conducted.

TL;DR: The primary objective of ARISTOTLE is to determine if the factor Xa inhibitor, apixaban, is noninferior to warfarin at reducing the combined endpoint of stroke (ischemic or hemorrhagic) and systemic embolism in patients with AF and at least 1 additional risk factor for stroke.

TL;DR: Nearly 1 in 5 participants in Chronic Renal Insufficiency Cohort, a national study of CKD, had evidence of AF at study entry, a prevalence similar to that reported among patients with end-stage renal disease and 2 to 3 times of that reported in the general population.

TL;DR: In highly selected patients considered for CTO recanalization, successful attempts appear to be associated with an improvement in mortality and with a reduction for the need for CABG as compared to failed recanAlization.

TL;DR: In this article, the effect of RHR on end points in the National FINRISK Study was analyzed, and a strong, graded, independent relationship between RHR and incident CVD was demonstrated.

TL;DR: SHARP should provide evidence about the efficacy and safety of lowering LDL cholesterol with the combination of ezetimibe and simvastatin among a wide range of patients with CKD.

TL;DR: Despite close follow-up and evidence-based therapy within a clinical trial, rehospitalization and death remain high and although most deaths were from HF, one quarter of patients had SCD, and there were almost as many non-CV hospitalizations as HF hospitalizations.

TL;DR: The present report describes the clinical characteristics of patients with AHFS in Japan based on the preliminary data collected in this study, and the similarities and differences in characteristics of these patients compared with those in Western countries.

TL;DR: The use of VCDs is associated with a significantly shorter time to hemostasis and thus may shorten recovery, however, theUse of V CDs isassociated with a somewhat increased risk of infection, lower limb ischemia/arterial stenosis/device entrapment in the artery, and need of vascular surgery for arterial complications.

TL;DR: High on-clopidogrel platelet reactivity, measured by an ADP-specific platelet function assay, is a strong predictor of CV death, MI, and ST in patients after percutaneous coronary intervention.

TL;DR: The results do not support the findings of smaller studies and suggest that statin treatment and serum low-density lipoprotein concentrations may have no benefit in reducing AAA progression.

TL;DR: The EVEREST II Trial is a multicenter, randomized controlled trial to evaluate the benefits and risks of endovascular mitral valve repair using the MitraClip device compared with open mitral valves surgery (control) in patients with moderate or severe MR.

TL;DR: Parity was associated with incident maternal CVD in a J-shaped fashion, even after accounting for socioeconomic factors and pregnancy-related complications, and 2 births representing the nadir of risk.

TL;DR: Clinical judgment and the Heart Team concept should play a key role in selecting patients for TAVI, whereas currently available surgical risk score algorithms should be used to guide clinical decision making.

TL;DR: Based on the genetic analysis in a high-risk population of acute MI patients with interventional treatment and continuous clopidogrel therapy, a protective effect for carriers of an increased-function CYP2C19*17 T-allele with significantly lower rates of TLR and MACE is found.

TL;DR: By evaluating the use of apixaban as a replacement for ASA in AF patients who are not treated with a VKA, the AVERROES study is addressing an important unmet clinical need.

TL;DR: The term randomized clinical registry trial is proposed to describe the novel entity of using an online national registry as platform for case records, randomization, and follow-up in patients with STEMI.

TL;DR: This randomized trial is designed to define the relative safety and effectiveness of 12 versus 30 months of dual antiplatelet therapy across the broad spectrum of patients receiving coronary stents.

TL;DR: The BioImage Study will help identify those patients with subclinical atherosclerosis who are at risk for near-term atherothrombotic events and enable a more personalized management of care.

TL;DR: The MetSyn and most of its components were associated with a higher risk of AF in both blacks and whites in this large cohort of participants of the Atherosclerosis Risk in Communities study.

TL;DR: Preexisting disturbance of cardiac conduction, a narrow left ventricular outflow tract, and the severity of mitral annular calcification predict the need for permanent pacing, whereas the only factor shown to be predictive for new-onset LBBB is the depth of prosthesis implantation.

TL;DR: Among a CV population > or =50 years with no history of depression, vitD levels were shown to be associated with incident depression after vitD draw, strengthening the hypothesis of the association between vitD and depression.

TL;DR: Hypoalbuminemia is common among patients withADHF and is independently associated with increased one year mortality in patients admitted with ADHF, and was mainly predictive of outcomes among those with systolic HF.

TL;DR: The antihypertensive effects of exercise intensity occurred in dose response fashion and Clinicians should weigh the benefits and risks of prescribing vigorous exercise intensity for those with hypertension on an individual basis.

TL;DR: In a large population of highly trained athletes, a mild enlargement of LA volume index was relatively common and may be regarded as a physiologic adaptation to exercise conditioning.

TL;DR: The CRYSTAL AF trial is a randomized prospective study to evaluate a novel approach to long-term monitoring for AF detection in patients with cryptogenic stroke using an insertable cardiac monitor.

TL;DR: The evidence for ECG interpretation strategies that either increase diagnostic specificity for "classic" STEMI and left bundle-branch block or improve diagnostic sensitivity in identifying 4 STEMI-equivalents are reviewed, including posterior MI, acute left main occlusion, de Winter ST/T-wave complex, and certain scenarios of resuscitated cardiac arrest.

TL;DR: The quantitative assessment of ADP-stimulated platelet-fibrin clot strength measured by thrombelastography can serve as a future tool in investigations of personalized antiplatelet treatment designed to reduce ischemic events and bleeding.

TL;DR: Limited data show that copeptin may, when used together with cardiac troponin, improve the sensitivity for diagnosing acute myocardial infarction, and growth differentiation factor 15 may help in selection of patients that benefit from invasive therapy.