V
Viktor Petukhov
Researcher at Harvard University
Publications - 14
Citations - 2719
Viktor Petukhov is an academic researcher from Harvard University. The author has contributed to research in topics: Biology & Epilepsy. The author has an hindex of 5, co-authored 7 publications receiving 1416 citations. Previous affiliations of Viktor Petukhov include University of Copenhagen & Saint Petersburg State Polytechnic University.
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Journal ArticleDOI
RNA velocity of single cells
Gioele La Manno,Gioele La Manno,Ruslan A. Soldatov,Amit Zeisel,Amit Zeisel,Emelie Braun,Emelie Braun,Hannah Hochgerner,Hannah Hochgerner,Viktor Petukhov,Viktor Petukhov,Katja Lidschreiber,Maria Eleni Kastriti,Peter Lönnerberg,Peter Lönnerberg,Alessandro Furlan,Jean Fan,Lars E. Borm,Lars E. Borm,Zehua Liu,David van Bruggen,Jimin Guo,Xiaoling He,Roger A. Barker,Erik Sundström,Gonçalo Castelo-Branco,Patrick Cramer,Patrick Cramer,Igor Adameyko,Sten Linnarsson,Sten Linnarsson,Peter V. Kharchenko +31 more
TL;DR: It is shown that RNA velocity—the time derivative of the gene expression state—can be directly estimated by distinguishing between unspliced and spliced mRNAs in common single-cell RNA sequencing protocols, and expected to greatly aid the analysis of developmental lineages and cellular dynamics, particularly in humans.
Journal ArticleDOI
Joint analysis of heterogeneous single-cell RNA-seq dataset collections
Nikolas Barkas,Viktor Petukhov,Viktor Petukhov,Daria Nikolaeva,Yaroslav Lozinsky,Samuel Demharter,Konstantin Khodosevich,Peter V. Kharchenko +7 more
TL;DR: Conos constructs a joint graph between single cells in different samples based on multiple pairwise alignments of the samples and identifies recurrent subpopulations across all of the datasets.
Journal ArticleDOI
Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis.
Ulrich Pfisterer,Viktor Petukhov,Viktor Petukhov,Samuel Demharter,Johanna Meichsner,Jonatan J Thompson,Mykhailo Y. Batiuk,Andrea Asenjo-Martinez,Navneet A. Vasistha,Ashish Thakur,Jens D. Mikkelsen,Istvan Adorjan,Lars H. Pinborg,Tune H. Pers,Jakob von Engelhardt,Peter V. Kharchenko,Konstantin Khodosevich +16 more
TL;DR: Overall, the data reveal a neuronal subtype-specific molecular phenotype of epilepsy, highlighted by layer-wise transcriptional changes in multiple glutamate receptor genes and strong upregulation of genes coding for AMPA receptor auxiliary subunits.
Journal ArticleDOI
Cell segmentation in imaging-based spatial transcriptomics.
Viktor Petukhov,Viktor Petukhov,Rosalind J. Xu,Rosalind J. Xu,Ruslan A. Soldatov,Paolo Cadinu,Paolo Cadinu,Konstantin Khodosevich,Jeffrey R. Moffitt,Jeffrey R. Moffitt,Peter V. Kharchenko +10 more
TL;DR: Baysor as discussed by the authors optimizes two-dimensional or three-dimensional cell boundaries considering joint likelihood of transcriptional composition and cell morphology, and performs cell segmentation based on transcripts detected by multiplexed FISH or in situ sequencing.
Posted ContentDOI
RNA velocity in single cells
Gioele La Manno,Gioele La Manno,Ruslan A. Soldatov,Hannah Hochgerner,Hannah Hochgerner,Amit Zeisel,Amit Zeisel,Viktor Petukhov,Viktor Petukhov,Maria Eleni Kastriti,Peter Lönnerberg,Peter Lönnerberg,Alessandro Furlan,Jean Fan,Zehua Liu,David van Bruggen,David van Bruggen,Jimin Guo,Erik Sundström,Gonçalo Castelo-Branco,Gonçalo Castelo-Branco,Igor Adameyko,Sten Linnarsson,Sten Linnarsson,Peter V. Kharchenko +24 more
TL;DR: It is shown that RNA velocity—the time derivative of RNA abundance—can be estimated by distinguishing unspliced and spliced mRNAs in standard single-cell RNA sequencing protocols, and expects RNA velocity to greatly aid the analysis of developmental lineages and cellular dynamics, particularly in humans.