U
Ulrich Pfisterer
Researcher at University of Copenhagen
Publications - 30
Citations - 1829
Ulrich Pfisterer is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Induced pluripotent stem cell & Progenitor cell. The author has an hindex of 11, co-authored 25 publications receiving 1443 citations. Previous affiliations of Ulrich Pfisterer include Science for Life Laboratory & Lund University.
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Journal ArticleDOI
Direct conversion of human fibroblasts to dopaminergic neurons
Ulrich Pfisterer,Agnete Kirkeby,Olof Torper,James Wood,Jenny Nelander,Audrey Dufour,Anders Björklund,Olle Lindvall,Johan Jakobsson,Malin Parmar +9 more
TL;DR: It is shown that the same strategy can be applied to human embryonic and postnatal fibroblasts and it is demonstrated that the converted neurons can be directed toward distinct functional neurotransmitter phenotypes when the appropriate transcriptional cues are provided together with the three conversion factors.
Journal ArticleDOI
Generation of induced neurons via direct conversion in vivo.
Olof Torper,Ulrich Pfisterer,Daniel Wolf,Maria Pereira,Shong Lau,Johan Jakobsson,Anders Björklund,Shane Grealish,Malin Parmar +8 more
TL;DR: It is shown that transplanted human fibroblasts and human astrocytes, which are engineered to express inducible forms of neural reprogramming genes, convert into neurons when reprograming genes are activated after transplantation.
Journal ArticleDOI
A community-based transcriptomics classification and nomenclature of neocortical cell types
Rafael Yuste,Michael Hawrylycz,Nadia Aalling,Argel Aguilar-Valles,Detlev Arendt,Rubén Armañanzas Arnedillo,Giorgio A. Ascoli,Concha Bielza,VS Bokharaie,Tobias Bergmann,Irina Bystron,Marco Capogna,YoonJeung Chang,Ann M. Clemens,Christiaan P. J. de Kock,Javier DeFelipe,Sandra E. Dos Santos,Keagan Dunville,Dirk Feldmeyer,Richárd Fiáth,Gordon Fishell,Angelica Foggetti,Xuefan Gao,Parviz Ghaderi,Natalia A. Goriounova,Onur Güntürkün,Kenta Hagihara,Vanessa Jane Hall,Moritz Helmstaedter,Suzana Herculano,Markus M. Hilscher,Hajime Hirase,Jens Hjerling-Leffler,Rebecca D. Hodge,Josh Huang,Rafiq Huda,Konstantin Khodosevich,Ole Kiehn,Henner Koch,Eric S. Kuebler,Malte Kühnemund,Pedro Larrañaga,Boudewijn P. F. Lelieveldt,Emma Louise Louth,Jan H. Lui,Huibert D. Mansvelder,Oscar Marín,Julio Martinez-Trujillo,Homeira Moradi Chameh,Alok Nath,Pavel Němec,Netanel Ofer,Ulrich Pfisterer,Samuel Pontes,William John Redmond,Jean Rossier,Joshua R. Sanes,Richard H. Scheuermann,Esther Serrano-Saiz,Jochen F. Steiger,Peter Somogyi,Gábor Tamás,Andreas S. Tolias,Maria Antonietta Tosches,Miguel Turrero García,Hermany Munguba Vieira,Christian Wozny,Thomas V. Wuttke,Liu Yong,Juan Yuan,Hongkui Zeng,Ed S. Lein +71 more
TL;DR: This work proposes the adoption of a transcriptome-based taxonomy of cell types for mammalian neocortex that should be hierarchical and use a standardized nomenclature, and could serve as an example for cell type atlases in other parts of the body.
Journal ArticleDOI
Neuronal survival in the brain: neuron type-specific mechanisms.
TL;DR: This review focuses on how immature neurons survive during normal and impaired brain development, both in the embryonic/neonatal brain and in brain regions associated with adult neurogenesis, and emphasizes neuron type-specific mechanisms that help to survive for various types of immature neurons.
Journal ArticleDOI
Efficient induction of functional neurons from adult human fibroblasts.
Ulrich Pfisterer,James Wood,Kristian Nihlberg,Oskar Hallgren,Leif Bjermer,Gunilla Westergren-Thorsson,Olle Lindvall,Malin Parmar +7 more
TL;DR: It is demonstrated for the first time that functional neurons can be generated via direct conversion of fibroblasts also from adult individuals, making this technology an attractive alternative to iPS cells for generating patient- and disease-specific neurons suitable for disease modeling and autologous transplantation.