Walter Berger

TL;DR: Hager et al. as discussed by the authors investigated the molecular signaling behind paraptosis as well as the reasons behind the induction of this quite unknown form of cell death by TSCs and found an upregulation of the coppersensitive and thiol-containing protein disulfide isomerase (PDI), which was confirmed on protein level.

TL;DR: FGFR blockade by a tyrosine kinase inhibitor or by a dominant-negative receptor construct resulted in reduced MPM growth in vitro and in vivo and enhanced the efficacy of chemo- or radiotherapy.

TL;DR: In this article , spatial transcriptomics (10X Visium) of tumor specimens matching their previously generated single-cell transcriptome data spanning all EPN subtypes (ZFTA, YAP1, PFA, PFB) was used to characterize the spatial architecture and elucidate regulatory circuits in EPN via spatial transcriptomic data, which revealed presence of distinct intratumoral cell states within ependymoma tissue and reveal their spatial organization.

TL;DR: The CDK4/6 clinically approved inhibitor abemaciclib shows promising efficacy against high-risk MB in vitro and in vivo, and within the ITCC-P4 project, single mouse trials are currently being performed including abemACiclib treatment in orthotopic MB models.

TL;DR: In this paper , the authors reported a dose-dependent pro-apoptotic action of synthetic cannabimimetic N-stearoylethanolamine (NSE) on diverse cancer cell lines, including multidrug-resistant models.