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Walter Berger
Researcher at Medical University of Vienna
Publications - 396
Citations - 16667
Walter Berger is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Cancer & Cell culture. The author has an hindex of 63, co-authored 359 publications receiving 14045 citations. Previous affiliations of Walter Berger include University of Vienna & Université libre de Bruxelles.
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Journal ArticleDOI
Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(IV)-based anticancer agents
Sarah Theiner,Christoph Kornauth,Hristo P. Varbanov,Markus Galanski,Sushilla Van Schoonhoven,Sushilla Van Schoonhoven,Petra Heffeter,Petra Heffeter,Walter Berger,Walter Berger,Alexander E. Egger,Bernhard K. Keppler +11 more
TL;DR: This is the first LA-ICP-MS study on spatially-resolved platinum accumulation in tissues after repetitive platinum-based anticancer drug treatment of mice bearing a preclinical tumor model and predicts the side effects based on bioimaging data by LA-ICP-MS should be considered with caution.
Journal ArticleDOI
Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention
Christian R. Kowol,Walter Miklos,Sarah Pfaff,Sonja Hager,Sebastian Kallus,Karla Pelivan,Mario Kubanik,Éva A. Enyedy,Walter Berger,Walter Berger,Petra Heffeter,Petra Heffeter,Bernhard K. Keppler +12 more
TL;DR: While only the “completely” methylated compound exerted nanomolar activity, the data revealed that all compounds with at least one N-dimethylation were not affected by acquired Triapine resistance.
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Another step toward DNA selective targeting: NiII and CuII complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes
Alessio Terenzi,Alessio Terenzi,Daniela Lötsch,Sushilla van Schoonhoven,Alexander Roller,Christian R. Kowol,Christian R. Kowol,Walter Berger,Bernhard K. Keppler,Bernhard K. Keppler,Giampaolo Barone +10 more
TL;DR: A new water soluble Salen-like Schiff base ligand and its Ni(II) and Cu( II) metal complexes are designed, synthesized and characterized and indicated that the nickel complex can stabilize oncogene promoter G-quadruplexes with high selectivity, presenting no interactions with duplex DNA at all.
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Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase
Véronique Mathieu,Aurélie Chantôme,Florence Lefranc,Alessio Cimmino,Walter Miklos,Verena Paulitschke,Thomas Mohr,Lucia Maddau,Alexander Kornienko,Walter Berger,Christophe Vandier,Antonio Evidente,Eric Delpire,Robert Kiss +13 more
TL;DR: The modulation of ion-transporter activity as a promising therapeutic strategy to combat drug-resistant cancers is underscored and the fungal metabolite, sphaeropsidin A, is identified as a lead to develop anticancer agents targeting RVI in cancer cells.
Journal ArticleDOI
Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis.
Beatrix Schoenhacker-Alte,Thomas Mohr,Christine Pirker,Kushtrim Kryeziu,Paul-Steffen Kuhn,Alicia Buck,Thilo Hofmann,Christopher Gerner,Gerrit Hermann,Gunda Koellensperger,Bernhard K. Keppler,Walter Berger,Petra Heffeter +12 more
TL;DR: The biochemical response to KP1339 was analyzed using whole genome expression arrays indicating that, while sensitive cell lines were characterized by "response to chemical stimuli" and "regulation of cell death", low-responsive cells preferentially activated pathways controlling cell cycle, DNA repair, and metabolism.