Walter Berger

TL;DR: It is reported here that TRIM52 ablation significantly diminished the proliferation of specific glioblastoma cell lines in cell culture and mouse xenografts by compromising their cell cycle progression in a p53-dependent manner.

TL;DR: It is shown that both the microfilament-disrupting and the cytotoxic activity of cytochalasins are reduced in parallel with increased P-gp expression and restorable by P-GP-modulating agents, and the polykaryon-inducing activity of Cytochalasin D is suggested as a specific indicator for a P- gp-mediated multidrug-resistance phenotype and the reversing potency of chemosensitizers.

TL;DR: In this article, the authors encapsulated Triapine into polymeric nanoparticles and remote-loaded liposomes to improve the drug pharmacokinetics as well as targeted delivery, but burst release of triapine from both nano-formulations was observed, making the synthesis of two novel triapy derivatives necessary in order to improve remoteloading properties.

TL;DR: ETV1 expression is a rare event in human melanoma and seems to be rather based on hyperactivation of MAPK signals, by BRAFV600E mutation, than on ETV1 gene amplification, Consequently, therapeutic inhibition of BRAF and the downstream MAPK pathway also down-regulates oncogenic ETV 1 expression.

TL;DR: Both Sorafenib and Sunitinib with Enzastaurin at concentrations feasible in vivo showed a synergistic reduction of viable RCC cells by inhibiting cell growth through inhibition of phospho-S6-kinase and GSK3-beta.