W
Walter Berger
Researcher at Medical University of Vienna
Publications - 396
Citations - 16667
Walter Berger is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Cancer & Cell culture. The author has an hindex of 63, co-authored 359 publications receiving 14045 citations. Previous affiliations of Walter Berger include University of Vienna & Université libre de Bruxelles.
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Journal ArticleDOI
Cancer cell resistance against the clinically investigated thiosemicarbazone COTI-2 is based on formation of intracellular copper complex glutathione adducts and ABCC1-mediated efflux
Julia H Bormio Nunes,Julia H Bormio Nunes,Sonja Hager,Marlene Mathuber,Vivien Pósa,Alexander Roller,Éva A. Enyedy,Alessia Stefanelli,Walter Berger,Bernhard K. Keppler,Petra Heffeter,Christian R. Kowol +11 more
TL;DR: Only thiosemicarbazones forming stable, nonreducible copper(II)-glutathione adducts are recognized and, in turn, effluxed by ABCC1, revealing a crucial connection between copper complex chemistry, glutathione interaction, and the resistance profile of clinically relevant thiosesmicarbzones.
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Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Ute Jungwirth,Johannes Gojo,Theresa Tuder,Gernot Walko,Martin Holcmann,Thomas Schöfl,Karin Nowikovsky,Nastasia Wilfinger,Sushilla van Schoonhoven,Christian R. Kowol,Rosa Lemmens-Gruber,Petra Heffeter,Petra Heffeter,Bernhard K. Keppler,Walter Berger,Walter Berger +15 more
TL;DR: Integrin deregulation via a calpain-mediated mechanism is identified as a novel mode of action for the anticancer gallium compound KP46 focusing on colon and lung cancer.
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Preclinical studies on metal based anticancer drugs as enabled by integrated metallomics and metabolomics
Luis Galvez,Mate Rusz,Michaela Schwaiger-Haber,Yasin El Abiead,Gerrit Hermann,Ute Jungwirth,Walter Berger,Bernhard K. Keppler,Bernhard K. Keppler,Michael A. Jakupec,Michael A. Jakupec,Gunda Koellensperger +11 more
TL;DR: A novel -omics workflow enabling the parallel study of platinum drug uptake and its distribution between nucleus/protein and small molecule fraction along with metabolic changes after different treatment time points is introduced.
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Wnt1 Is Anti-Lymphangiogenic in a Melanoma Mouse Model
Heide Niederleithner,Magdalena Heinz,Stefanie Tauber,Stefanie Tauber,Martin Bilban,Hubert Pehamberger,Stefan Eugen Sonderegger,Martin Knöfler,Andreas Bracher,Walter Berger,Robert Loewe,Peter Petzelbauer +11 more
TL;DR: Wnt1 is anti-lymphangiogenic by suppressing melanoma-derived VEGF-C expression by suppressing it in melanoma cell lines in vivo.
Journal ArticleDOI
Erythropoietin Receptor Expression Is a Potential Prognostic Factor in Human Lung Adenocarcinoma
Anita Rozsas,Judit Berta,Lívia Rojkó,László Z. Horváth,Magdolna Keszthelyi,István Kenessey,Viktoria Laszlo,Walter Berger,Michael Grusch,Mir Alireza Hoda,Szilvia Török,Walter Klepetko,Ferenc Rényi-Vámos,Balázs Hegedűs,Balázs Hegedűs,Balazs Dome,József Tóvári +16 more
TL;DR: High EPOR level as a potential novel positive prognostic marker in human lung ADC is revealed, and in patients with advanced stage lung ADC, high intratumoral EPOR mRNA levels were associated with significantly increased overall survival.