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Walter Berger
Researcher at Medical University of Vienna
Publications - 396
Citations - 16667
Walter Berger is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Cancer & Cell culture. The author has an hindex of 63, co-authored 359 publications receiving 14045 citations. Previous affiliations of Walter Berger include University of Vienna & Université libre de Bruxelles.
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Combined MEK and PI3K/p110β Inhibition as a Novel Targeted Therapy for Malignant Mesothelioma Displaying Sarcomatoid Features.
Miriam Marqués,Robin Tranchant,Blanca Risa-Ebrí,María L. Suárez-Solís,Luis C. Fernández,Enrique Carrillo-de-Santa-Pau,Natalia del Pozo,Jaime Martinez de Villarreal,Clément Meiller,Yves Allory,Yuna Blum,Christine Pirker,Balazs Hegedus,Simon T. Barry,Amancio Carnero,Walter Berger,Didier Jean,Francisco X. Real +17 more
TL;DR: These findings provide a rationale for the use of Selumetinib and AZD8186 in MM patients with sarcomatoid features, and constitute a novel targeted therapy for a poor prognosis and frequently chemoresistant group of MM patients, for whom therapeutic options are currently lacking.
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Irinotecan Upregulates Fibroblast Growth Factor Receptor 3 Expression in Colorectal Cancer Cells, Which Mitigates Irinotecan-Induced Apoptosis.
Zeynep Erdem,Stefanie Schwarz,Daniel Drev,Christine Heinzle,Andrea Réti,Petra Heffeter,Xenia Hudec,Klaus Holzmann,Bettina Grasl-Kraupp,Walter Berger,Michael Grusch,Brigitte Marian +11 more
TL;DR: It is indicated that targeting FGFR3 can be a promising strategy to enhance IRI response in CRC patients and acted synergistically with the chemotherapeutic drug and significantly enhanced IRI-induced caspase 3 activity in vitro.
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Ruthenium–arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition
Laura A. Hager,Stephan Mokesch,Claudia Kieler,Silvia Alonso-de Castro,Dina Baier,Alexander Roller,Wolfgang Kandioller,Bernhard K. Keppler,Walter Berger,Luca Salassa,Luca Salassa,Alessio Terenzi,Alessio Terenzi +12 more
TL;DR: Improvements on the hydrolytic stability of ruthenium arene complexes are shown, by substituting the chlorido leaving ligand with pyridine, have a dramatic impact on their interaction with quadruplexes and on their cytotoxicity against ovarian cancer cells.
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Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs.
Claudia Karnthaler-Benbakka,Diana Groza,Bettina Koblmüller,Alessio Terenzi,Alessio Terenzi,Katharina Holste,Melanie Haider,Dina Baier,Walter Berger,Petra Heffeter,Christian R. Kowol,Christian R. Kowol,Bernhard K. Keppler,Bernhard K. Keppler +13 more
TL;DR: Significant differences in the impact of structural modifications on drug binding to the enzymes were revealed and proof of principle could be shown for this concept, and the results obtained are an important basis for the future development of tyrosine kinase inhibitor prodrugs.
Journal ArticleDOI
Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones
Petra Heffeter,Christine Pirker,Christian R. Kowol,Gerrit Herrman,R. Dornetshuber,R. Dornetshuber,Walter Miklos,Ute Jungwirth,Gunda Koellensperger,Bernhard K. Keppler,Walter Berger +10 more
TL;DR: In this article, a new cell model with acquired resistance against the lead compound KP1089 was established, which suggests that terminal dimethylation of thiosemicarbazones leads to altered resistance profiles.