Walter Berger

TL;DR: Thiol-induced intracellular ROS generation might contribute to the anticancer activity of copper thiosemicarbazone complexes but is not the determining factor, while experiments on generation of oxidative stress and the influence of biologically relevant reductants revealed that reductant-dependent redox cycling occurred mainly outside the cells.

TL;DR: The results suggest that short-term exposure to very low ENN concentrations, for example, via food intake, might have tumor-promoting functions based on growth stimulation, suggesting a potential quality of ENN as an anticancer drug.

TL;DR: In this paper, the eEF1A targeting with narciclasine (50 nM) leads to marked actin cytoskeleton disorganization, resulting in cytokinesis impairment, and protein synthesis impairment (elongation and initiation steps), whereas apoptosis is induced at higher doses only (≥200 nM).

TL;DR: In this paper, the authors employed a chemical proteomic approach to identify the molecular targets of an antimetastatic ruthenium organometallic complex based on 1,3,5-triaza-7phosphaadamantane (RAPTA).

TL;DR: The results suggest that Spry2 plays a role as tumor suppressor in NSCLC by antagonizing receptor tyrosine kinase–induced signaling at different levels, indicating feasibility for the usage of Spry in targeted gene therapy of NSCLCs.