Showing papers in "Journal of Asian Natural Products Research in 2012"

TL;DR: Three new phenolic compounds, nicotphenols A–C (1–3), together with 14 known phenols (4–17), were isolated from the leaves of Nicotiana tabacum and showed significant cytotoxic abilities and modest anti-HIV-1 activities, respectively.

TL;DR: This review based on 45 literary sources discusses the current knowledge of traditional uses, chemistry, biological effects, and toxicity of different species of this genus Grewia.

TL;DR: It is demonstrated that galangin induces apoptosis in HCCs by activating caspase 8/t-Bid mitochondrial pathway and is attenuated by Z-IETD-FMK, Bid siRNA, and Bcl-2 overexpression, respectively.

TL;DR: The following information is an attempt to cover the developments in the biology and phytochemistry of 1,4-naphthoquinones isolated from this genus, as well as the studies done and the suggested mechanisms regarding their activities.

TL;DR: Through promoting Sirt-1 expression and recovering autophagy physiologically, silibinin may reverse hyperglycemia and repair damaged pancreatic β-cells.

TL;DR: Four new N-contained iridoid glycosides were isolated from the flower buds of Lonicera japonica Thunb and established on the basis of UV, IR, MS, and NMR spectral data.

TL;DR: The novel seco-ursane-type triterpenoid 3β,11α-dihydroxy-17,22-seco-17(28), 12-ursadien-22-oic acid was isolated for the first time from a natural source from two Salvia species growing wild in Jordan, Salvia palaestina Benth and S. syriaca.

TL;DR: Four new triterpenoids, psiguanins A–D, along with 13 known ones, were isolated from the leaves of Psidium guajava, and compound 4 was characterized as an unusual ursane-type triter penoid with cis-fused C/D ring system.

TL;DR: It is suggested that ISL treatment induced apoptosis by increasing intracellular ROS levels in HeLa cells by inhibiting cell proliferation by inducing apoptosis.

TL;DR: The results showed that STS could reduce the damage of PRRSV to Marc-145 cells, with the inhibition ratio exceeding to 100%, at the maximum non-cytotoxic concentration.

TL;DR: Taken together, ER, p38 MAPK, and Wnt/β-catenin pathways were involved in puerarin-stimulated osteoblasts differentiation and bone formation.

TL;DR: Three new sesquiterpenes, including C-10 in compounds 1–3 of a rare class was determined by using Snatzke's method and their structures were established on the basis of extensive spectroscopic analysis and chemical shifts.

TL;DR: Two new flavonoids, named cambodianins D and E, together with two known flavanes, including (2S)-7,4′-dihydroxy-6,8-dimethylflavane, were isolated from dragon's blood of Dracaena camboda.

TL;DR: The findings indicated that the possibility of food–drug interactions mediated by Capsaicin and dihydrocapsaicin could not be excluded, and provided the useful information for evaluating the anticarcinogenic potentials of these two capsaicinoids.

TL;DR: These compounds were evaluated for their effect on the inhibition of nitric oxide production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and for 1,1-diphenyl-2-picrylhydrazyl free-radical scavenging activity in cell-free bioassay system.

TL;DR: Investigation of whether SAA exhibits its protective effects in rats subjected to middle cerebral artery occlusion through sEH and EETs showed that SAA treatment ameliorated neurological deficits and reduced infarct volume, suggesting cerebral protection of SAA is mediated, at least in part, via inhibiting sEH to increase E ETs levels.

TL;DR: The findings demonstrate that the passive transport process may be the main process for PCB to pass through the BBB, and P-gp is likely to have a little effect on the PCB transport process, and PCB may not affect the functional activity and the protein expression of the P- gp transporter at theBBB.

TL;DR: A new flavonoid glycoside was isolated from the leaves of Aquilaria sinensis (Lour.) Gilg and its structure was elucidated by spectroscopic analyses, and exhibited a potent inhibitory activity against NO production in a dose-dependent manner.

TL;DR: The antivirus effect of quercetin and oseltamivir on the Toll-like receptor 7 (TLR7) signaling pathway was observed when dendritic cells and macrophages were infected with H1N1 and increased cell viability and reduced the expression levels of TLR7 signal pathway.

TL;DR: Two new compounds, penicillone A andpenicillactam, were isolated together with 17 known compounds from a marine-derived fungus Penicillium sp.

TL;DR: Two new phenolic glycosides, named parishins F–G (1–2), together with known parishin E, were isolated from the rhizome of Gastrodia elata by means of MS, 1D, and 2D NMR spectral analyses, as well as chemical methods.

TL;DR: Asiatic acid is a natural triterpenoid possessing anti-inflammatory, anticancer, neuroprotective, and hepatoprotective activities and structural modification of AA may provide valuable information for further structure–activity relationship analysis.

TL;DR: Most of the derivatives of asiatic acid derivatives were found to have stronger cell growth inhibitory activity than AA and exhibited more potent cytotoxicity than AA, Gefitinib, and etoposide.

TL;DR: Two new iridoids, jatamanvaltrates N (1) and O (2), together with four known compounds, were isolated from the roots of Valeriana jatamansi and only compound 1 showed weak neuroprotective activities.

TL;DR: A series of new bisbenzylisoquinoline alkaloids was partially synthesized from tetrandrine and fangchinoline and evaluated for their ability to reverse P-glycoprotein-mediated multidrug resistance in cancer cells, and most exhibited more potent MDR-reversing activity relative to the reference compound verapamil.

TL;DR: The chemical investigation on the n-hexane extract of Withania somnifera roots has yielded octacosane, oleic and stearic fatty acids, stigmasterone, Stigmasterol, sitostanone, oleanolic acid along with the ergosterol and 1,4-dioxane derivatives as new compounds.

TL;DR: Two new C13-norisoprenoids, named lyratols E and F, were isolated from the whole plant of Solanum lyratum Thunb, and their structures were elucidated by extensive spectroscopic analyses.

TL;DR: Moracins O (6) and P (10) showed inhibitory effects on mushroom tyrosinase with IC50 values being lower than that of kojic acid.

TL;DR: Five compounds were isolated from the root powder of Periploca sepium and found to possess insecticidal activities against the red imported fire ant.

TL;DR: A new prenylated aurone is isolated from methanol extract of Artocarpus altilis together with eight known compounds, which showed moderate nitric oxide radical scavenging activity, whereas 2 and 3 had moderate 2,2-diphenyl-1-picrylhydrazylradical scavenging effect, compared with the positive control (+)-catechin.