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Wendy Liang
Researcher at University of Toronto
Publications - 4
Citations - 2437
Wendy Liang is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Mutation (genetic algorithm). The author has an hindex of 4, co-authored 4 publications receiving 2245 citations.
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Journal ArticleDOI
The genetic landscape of a cell.
Michael Costanzo,Anastasia Baryshnikova,Jeremy Bellay,Yungil Kim,Eric D. Spear,Carolyn S. Sevier,Huiming Ding,Judice L. Y. Koh,Kiana Toufighi,Sara Mostafavi,Jeany Prinz,Robert P. St.Onge,Benjamin VanderSluis,Taras Makhnevych,Franco J. Vizeacoumar,Solmaz Alizadeh,Sondra Bahr,Renee L. Brost,Yiqun Chen,Murat Cokol,Raamesh Deshpande,Zhijian Li,Zhen Yuan Lin,Wendy Liang,Michaela Marback,Jadine Paw,Bryan Joseph San Luis,Ermira Shuteriqi,Amy Hin Yan Tong,Nydia Van Dyk,Iain M. Wallace,Joseph Whitney,Matthew T. Weirauch,Guoqing Zhong,Hongwei Zhu,Walid A. Houry,Michael Brudno,Sasan Ragibizadeh,Balázs Papp,Csaba Pál,Frederick P. Roth,Guri Giaever,Corey Nislow,Olga G. Troyanskaya,Howard Bussey,Gary D. Bader,Anne-Claude Gingras,Quaid Morris,Philip M. Kim,Chris A. Kaiser,Chad L. Myers,Brenda J. Andrews,Charles Boone +52 more
TL;DR: A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function.
Journal ArticleDOI
Exploring genetic suppression interactions on a global scale
Jolanda van Leeuwen,Carles Pons,Joseph C. Mellor,Joseph C. Mellor,Takafumi N. Yamaguchi,Takafumi N. Yamaguchi,Helena Friesen,John H. Koschwanez,Mojca Mattiazzi Usaj,Maria Pechlaner,Mehmet Takar,Matej Usaj,Benjamin VanderSluis,Kerry Andrusiak,Pritpal Bansal,Pritpal Bansal,Anastasia Baryshnikova,Claire E. Boone,Jessica Cao,Atina G. Cote,Atina G. Cote,Marinella Gebbia,Marinella Gebbia,Gene Horecka,Ira Horecka,Elena Kuzmin,Nicole Legro,Wendy Liang,Natascha van Lieshout,Natascha van Lieshout,Margaret McNee,Bryan-Joseph San Luis,Fatemeh Shaeri,Fatemeh Shaeri,Ermira Shuteriqi,Song Sun,Lu Yang,Ji-Young Youn,Michael Yuen,Michael Costanzo,Anne-Claude Gingras,Anne-Claude Gingras,Patrick Aloy,Chris Oostenbrink,Andrew W. Murray,Todd R. Graham,Chad L. Myers,Chad L. Myers,Brenda J. Andrews,Frederick P. Roth,Charles Boone,Charles Boone +51 more
TL;DR: A large-scale study in yeast reveals how defects associated with a mutation in one gene can be compensated for by a second mutation in a suppressor gene, and assembled a global network of genetic suppression interactions, which highlights the major potential for systematic studies of suppression to map cellular function.
Journal ArticleDOI
Systematic analysis of bypass suppression of essential genes.
Jolanda van Leeuwen,Jolanda van Leeuwen,Carles Pons,Guihong Tan,Jason Z Ya Wang,Jing Hou,Jochen Weile,Jochen Weile,Marinella Gebbia,Marinella Gebbia,Wendy Liang,Ermira Shuteriqi,Zhijian Li,Maykel Lopes,Matej Usaj,Andreia Dos Santos Lopes,Natascha van Lieshout,Natascha van Lieshout,Chad L. Myers,Frederick P. Roth,Patrick Aloy,Brenda J. Andrews,Charles Boone +22 more
TL;DR: Yeast's core essential gene set is identified and the properties of dispensable essential genes are conserved from yeast to human cells, correlating with human genes that display cell line‐specific essentiality in the Cancer Dependency Map (DepMap) project.
Journal ArticleDOI
Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library.
Ji-Young Youn,Helena Friesen,Alex N. Nguyen Ba,Wendy Liang,Vincent Messier,Michael J. Cox,Alan M. Moses,Brenda J. Andrews +7 more
TL;DR: Follow-up experiments validated regulatory relationships between genetically interacting pairs (Cdc28–Stb1 and Pho85–Pdr1), suggesting that GI studies involving OE alleles of regulatory proteins will be a rich source of new functional information.