W
Werner Koch
Researcher at Technische Universität München
Publications - 95
Citations - 6081
Werner Koch is an academic researcher from Technische Universität München. The author has contributed to research in topics: Myocardial infarction & Restenosis. The author has an hindex of 34, co-authored 95 publications receiving 5790 citations. Previous affiliations of Werner Koch include Max Planck Society & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Loss-of-function mutations in APOC3, triglycerides, and coronary disease
Jacy R Crosby,Gina M. Peloso,Gina M. Peloso,Paul L. Auer,David R. Crosslin,Nathan O. Stitziel,Leslie A. Lange,Yingchang Lu,Zheng-Zheng Tang,He Zhang,George Hindy,Nicholas G. D. Masca,Kathleen Stirrups,Stavroula Kanoni,Ron Do,Ron Do,Goo Jun,Youna Hu,Hyun Min Kang,Chenyi Xue,Anuj Goel,Martin Farrall,Stefano Duga,Pier Angelica Merlini,Rosanna Asselta,Domenico Girelli,Oliviero Olivieri,Nicola Martinelli,Wu Yin,Dermot F. Reilly,Elizabeth K. Speliotes,Caroline S. Fox,Kristian Hveem,Oddgeir L. Holmen,Majid Nikpay,Deborah N. Farlow,Themistocles L. Assimes,Nora Franceschini,Jennifer G. Robinson,Kari E. North,Lisa W. Martin,Mark A. DePristo,Namrata Gupta,Stefan A. Escher,Jan-Håkan Jansson,Natalie R. van Zuydam,Colin N. A. Palmer,Nicholas J. Wareham,Werner Koch,Thomas Meitinger,Annette Peters,Wolfgang Lieb,Raimund Erbel,Inke R. König,Jochen Kruppa,Franziska Degenhardt,Omri Gottesman,Erwin P. Bottinger,Christopher J. O'Donnell,Bruce M. Psaty,Bruce M. Psaty,Christie M. Ballantyne,Christie M. Ballantyne,Gonçalo R. Abecasis,Jose M. Ordovas,Jose M. Ordovas,Olle Melander,Hugh Watkins,Marju Orho-Melander,Diego Ardissino,Ruth J. F. Loos,Ruth McPherson,Cristen J. Willer,Jeanette Erdmann,Alistair S. Hall,Nilesh J. Samani,Panos Deloukas,Panos Deloukas,Panos Deloukas,Heribert Schunkert,James G. Wilson,Charles Kooperberg,Stephen S. Rich,Russell P. Tracy,Danyu Lin,David Altshuler,David Altshuler,Stacey Gabriel,Deborah A. Nickerson,Gail P. Jarvik,L. Adrienne Cupples,L. Adrienne Cupples,Alexander P. Reiner,Alexander P. Reiner,Eric Boerwinkle,Sekar Kathiresan,Sekar Kathiresan +96 more
TL;DR: Rare mutations that disrupt AP OC3 function were associated with lower levels of plasma triglycerides and APOC3, and carriers of these mutations were found to have a reduced risk of coronary heart disease.
Journal ArticleDOI
Cytochrome 2C19*17 Allelic Variant, Platelet Aggregation, Bleeding Events, and Stent Thrombosis in Clopidogrel-Treated Patients With Coronary Stent Placement
Dirk Sibbing,Werner Koch,Daniela Gebhard,Tibor Schuster,Siegmund Braun,Julia Stegherr,Tanja Morath,Albert Schömig,Nicolas von Beckerath,Adnan Kastrati +9 more
TL;DR: CYP2C19*17 carrier status is significantly associated with enhanced response to clopidogrel and an increased risk of bleeding andMultivariate analysis confirmed the independent association of CYP2C 19*17 allele carriage with platelet aggregation values and the occurrence of bleeding.
Journal ArticleDOI
Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention
Dirk Sibbing,Julia Stegherr,Wolfgang Latz,Werner Koch,Julinda Mehilli,Katharina Dörrler,Tanja Morath,Albert Schömig,Adnan Kastrati,Nicolas von Beckerath +9 more
TL;DR: CYP2C19*2 carrier status is significantly associated with an increased risk of stent thrombosis following coronary stent placement and the risk of ST was highest in patients with the CYP2C 19 *2/*2 genotype.
Journal ArticleDOI
Activated Platelets Induce Monocyte Chemotactic Protein-1 Secretion and Surface Expression of Intercellular Adhesion Molecule-1 on Endothelial Cells
Meinrad Gawaz,Franz-Josef Neumann,Timm Dickfeld,Werner Koch,Karl-Ludwig Laugwitz,Helmut Adelsberger,Kirsten Langenbrink,Sharon Page,Dieter Neumeier,Albert Schömig,Korbinian Brand +10 more
TL;DR: It is indicated that activated platelets modulate chemotactic (MCP-1) and adhesive (ICAM- 1) properties of endothelial cells via an NF-kappaB-dependent mechanism.
Journal ArticleDOI
Platelets induce alterations of chemotactic and adhesive properties of endothelial cells mediated through an interleukin-1-dependent mechanism. Implications for atherogenesis
Meinrad Gawaz,Korbinian Brand,Timm Dickfeld,Gisela Pogatsa-Murray,Sharon Page,Caroline Bogner,Werner Koch,Albert Schömig,Franz-Josef Neumann +8 more
TL;DR: It is concluded that activated platelets induce significant changes in chemotactic and adhesive properties of cultured endothelium and imply a potential pathophysiological mechanism of platelets in an early stage of atherogenesis.