J
Jochen Kruppa
Researcher at Humboldt University of Berlin
Publications - 73
Citations - 3612
Jochen Kruppa is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 20, co-authored 65 publications receiving 2791 citations. Previous affiliations of Jochen Kruppa include University of Lübeck & University of Göttingen.
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Journal ArticleDOI
Loss-of-function mutations in APOC3, triglycerides, and coronary disease
Jacy R Crosby,Gina M. Peloso,Gina M. Peloso,Paul L. Auer,David R. Crosslin,Nathan O. Stitziel,Leslie A. Lange,Yingchang Lu,Zheng-Zheng Tang,He Zhang,George Hindy,Nicholas G. D. Masca,Kathleen Stirrups,Stavroula Kanoni,Ron Do,Ron Do,Goo Jun,Youna Hu,Hyun Min Kang,Chenyi Xue,Anuj Goel,Martin Farrall,Stefano Duga,Pier Angelica Merlini,Rosanna Asselta,Domenico Girelli,Oliviero Olivieri,Nicola Martinelli,Wu Yin,Dermot F. Reilly,Elizabeth K. Speliotes,Caroline S. Fox,Kristian Hveem,Oddgeir L. Holmen,Majid Nikpay,Deborah N. Farlow,Themistocles L. Assimes,Nora Franceschini,Jennifer G. Robinson,Kari E. North,Lisa W. Martin,Mark A. DePristo,Namrata Gupta,Stefan A. Escher,Jan-Håkan Jansson,Natalie R. van Zuydam,Colin N. A. Palmer,Nicholas J. Wareham,Werner Koch,Thomas Meitinger,Annette Peters,Wolfgang Lieb,Raimund Erbel,Inke R. König,Jochen Kruppa,Franziska Degenhardt,Omri Gottesman,Erwin P. Bottinger,Christopher J. O'Donnell,Bruce M. Psaty,Bruce M. Psaty,Christie M. Ballantyne,Christie M. Ballantyne,Gonçalo R. Abecasis,Jose M. Ordovas,Jose M. Ordovas,Olle Melander,Hugh Watkins,Marju Orho-Melander,Diego Ardissino,Ruth J. F. Loos,Ruth McPherson,Cristen J. Willer,Jeanette Erdmann,Alistair S. Hall,Nilesh J. Samani,Panos Deloukas,Panos Deloukas,Panos Deloukas,Heribert Schunkert,James G. Wilson,Charles Kooperberg,Stephen S. Rich,Russell P. Tracy,Danyu Lin,David Altshuler,David Altshuler,Stacey Gabriel,Deborah A. Nickerson,Gail P. Jarvik,L. Adrienne Cupples,L. Adrienne Cupples,Alexander P. Reiner,Alexander P. Reiner,Eric Boerwinkle,Sekar Kathiresan,Sekar Kathiresan +96 more
TL;DR: Rare mutations that disrupt AP OC3 function were associated with lower levels of plasma triglycerides and APOC3, and carriers of these mutations were found to have a reduced risk of coronary heart disease.
Journal ArticleDOI
Overview of random forest methodology and practical guidance with emphasis on computational biology and bioinformatics
TL;DR: This paper synthesizes 10 years of RF development with emphasis on applications to bioinformatics and computational biology and some representative examples of RF applications in this context and possible directions for future research.
Journal ArticleDOI
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease
Nathan O. Stitziel,Kathleen Stirrups,Nicholas G. D. Masca,Jeanette Erdmann,Paola G. Ferrario,Inke R. Koenig,Peter Weeke,Tom R. Webb,Paul L. Auer,Ursula M. Schick,Yingchang Lu,He Zhang,Marie-Pierre Dubé,Anuj Goel,Martin Farrall,Gina M. Peloso,Hong-Hee Won,Ron Do,Erik P A Van Iperen,Stavroula Kanoni,Jochen Kruppa,Anubha Mahajan,Robert A. Scott,Christina Willenborg,Peter S. Braund,Julian C. van Capelleveen,Alex S. F. Doney,Louise A. Donnelly,Rosanna Asselta,Piera Angelica Merlini,Stefano Duga,Nicola Marziliano,Josh C. Denny,Christian M. Shaffer,Nour Eddine El-Mokhtari,Andre Franke,Omri Gottesman,Stefanie Heilmann,Christian Hengstenberg,Per Hoffmann,Oddgeir L. Holmen,Kristian Hveem,Jan-Håkan Jansson,Karl-Heinz Joeckel,Thorsten Kessler,Jennifer Kriebel,Karl L. Laugwitz,Eirini Marouli,Nicola Martinelli,Mark I. McCarthy,Natalie R. van Zuydam,Christa Meisinger,Tõnu Esko,Evelin Mihailov,Stefan A. Escher,Maris Alver,Susanne Moebus,Andrew D. Morris,Martina Mueller-Nurasyid,Majid Nikpay,Oliviero Olivieri,Louis-Philippe Lemieux Perreault,Alaa AlQarawi,Neil R. Robertson,Karen O. Akinsanya,Dermot F. Reilly,Thomas F. Vogt,Wu Yin,Folkert W. Asselbergs,Charles Kooperberg,Rebecca D. Jackson,Eli A. Stahl,Konstantin Strauch,Tibor V. Varga,Melanie Waldenberger,Lingyao Zeng,Aldi T. Kraja,Chunyu Liu,Georg Ehret,Christopher Newton-Cheh,Daniel I. Chasman,Rajiv Chowdhury,Marco M Ferrario,Ian Ford,J. Wouter Jukema,Frank Kee,Kari Kuulasmaa,Børge G. Nordestgaard,Markus Perola,Danish Saleheen,Naveed Sattar,Praveen Surendran,David-Alexandre Trégouët,Robin Young,Joanna M. M. Howson,Adam S. Butterworth,John Danesh,Diego Ardissino,Erwin P. Bottinger,Raimund Erbel,Paul W. Franks,Domenico Girelli,Alistair S. Hall,G. Kees Hovingh,Adnan Kastrati,Wolfgang Lieb,Thomas Meitinger,William E. Kraus,Svati H. Shah,Ruth McPherson,Marju Orho-Melander,Olle Melander,Andres Metspalu,Colin N. A. Palmer,Annette Peters,Daniel J. Rader,Muredach P. Reilly,Ruth J. F. Loos,Alexander P. Reiner,Dan M. Roden,Jean-Claude Tardif,John R. Thompson,Nicholas J. Wareham,Hugh Watkins,Cristen J. Willer,Sekar Kathiresan,Panos Deloukas,Nilesh J. Samani,Heribert Schunkert +128 more
TL;DR: It was found that carriers of loss-of-function mutations in ANGPTL4 had triglyceride levels that were lower than those among noncarriers; these mutations were also associated with protection from coronary artery disease.
Journal ArticleDOI
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
Tom R. Webb,Jeanette Erdmann,Kathleen Stirrups,Nathan O. Stitziel,Nicholas G. D. Masca,Henning Jansen,Stavroula Kanoni,Christopher P. Nelson,Paola G. Ferrario,Inke R. König,John D. Eicher,Andrew D. Johnson,Stephen E. Hamby,Christer Betsholtz,Arno Ruusalepp,Oscar Franzén,Eric E. Schadt,Johan Björkegren,Peter Weeke,Paul L. Auer,Ursula M. Schick,Ursula M. Schick,Yingchang Lu,He Zhang,Marie-Pierre Dubé,Anuj Goel,Martin Farrall,Gina M. Peloso,Hong-Hee Won,Ron Do,Erik P A Van Iperen,Jochen Kruppa,Anubha Mahajan,Robert A. Scott,Christina Willenborg,Peter S. Braund,Julian C. van Capelleveen,Alex S. F. Doney,Louise A. Donnelly,Rosanna Asselta,Pier Angelica Merlini,Stefano Duga,Nicola Marziliano,Josh C. Denny,Christian M. Shaffer,Nour Eddine El-Mokhtari,Andre Franke,Stefanie Heilmann,Christian Hengstenberg,Per Hoffmann,Oddgeir L. Holmen,Kristian Hveem,Jan-Håkan Jansson,Karl-Heinz Jöckel,Thorsten Kessler,Jennifer Kriebel,Karl L. Laugwitz,Eirini Marouli,Nicola Martinelli,Mark I. McCarthy,Natalie R. van Zuydam,Christa Meisinger,Tõnu Esko,Tõnu Esko,Tõnu Esko,Evelin Mihailov,Stefan A. Escher,Maris Alver,Susanne Moebus,Andrew D. Morris,Jarma Virtamo,Majid Nikpay,Oliviero Olivieri,Sylvie Provost,Alaa AlQarawi,Neil R. Robertson,Karen O. Akinsansya,Dermot F. Reilly,Thomas F. Vogt,Wu Yin,Folkert W. Asselbergs,Folkert W. Asselbergs,Charles Kooperberg,Rebecca D. Jackson,Eli A. Stahl,Martina Müller-Nurasyid,Konstantin Strauch,Tibor V. Varga,Melanie Waldenberger,Lingyao Zeng,Rajiv Chowdhury,Veikko Salomaa,Ian Ford,J. Wouter Jukema,Philippe Amouyel,Jukka Kontto,Børge G. Nordestgaard,Jean Ferrières,Danish Saleheen,Naveed Sattar,Praveen Surendran,Aline Wagner,Robin Young,Joanna M. M. Howson,Adam S. Butterworth,John Danesh,Diego Ardissino,Erwin P. Bottinger,Raimund Erbel,Paul W. Franks,Domenico Girelli,Alistair S. Hall,G. Kees Hovingh,Adnan Kastrati,Wolfgang Lieb,Thomas Meitinger,William E. Kraus,Svati H. Shah,Ruth McPherson,Marju Orho-Melander,Olle Melander,Andres Metspalu,Colin N. A. Palmer,Annette Peters,Daniel J. Rader,Muredach P. Reilly,Ruth J. F. Loos,Alexander P. Reiner,Alexander P. Reiner,Dan M. Roden,Jean-Claude Tardif,John R. Thompson,Nicholas J. Wareham,Hugh Watkins,Cristen J. Willer,Nilesh J. Samani,Heribert Schunkert,Panos Deloukas,Sekar Kathiresan +138 more
TL;DR: Several CAD loci show substantial pleiotropy, which may help us understand the mechanisms by which these loci affect CAD risk, and identify 6 new loci associated with CAD at genome-wide significance.
Journal ArticleDOI
Probability machines: consistent probability estimation using nonparametric learning machines.
TL;DR: Random forest algorithms as well as nearest neighbor approaches are valid machine learning methods for estimating individual probabilities for binary responses.