W
William Cross
Researcher at Queen Mary University of London
Publications - 66
Citations - 899
William Cross is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Scholarly communication & Open education. The author has an hindex of 14, co-authored 62 publications receiving 598 citations. Previous affiliations of William Cross include University College London & Cardiff University.
Papers
More filters
Journal ArticleDOI
The evolutionary landscape of colorectal tumorigenesis.
William Cross,William Cross,Michal Kovac,Michal Kovac,Ville Mustonen,Daniel Temko,Daniel Temko,Hayley Davis,Ann-Marie Baker,Sujata Biswas,Roland Arnold,Laura Chegwidden,Chandler Gatenbee,Alexander R. A. Anderson,Viktor H. Koelzer,Viktor H. Koelzer,Pierre Martinez,Xiaowei Jiang,Enric Domingo,Dan J. Woodcock,Yun Feng,Monika Kovacova,Tim Maughan,Marnix Jansen,Manuel Rodriguez-Justo,S Q Ashraf,R. Guy,Chris Cunningham,James E. East,David C. Wedge,Lai Mun Wang,Claire Palles,Karl Heinimann,Karl Heinimann,Andrea Sottoriva,Simon J. Leedham,Simon J. Leedham,Trevor A. Graham,Ian Tomlinson,Richard Adams +39 more
TL;DR: It is concluded that adenomas evolve across an undulating fitness landscape, whereas carcinomas occupy a sharper fitness peak, probably owing to stabilizing selection.
Journal ArticleDOI
Evolutionary history of human colitis-associated colorectal cancer
Ann-Marie Baker,William Cross,Kit Curtius,Ibrahim Al Bakir,Chang-Ho Ryan Choi,Hayley Davis,Daniel Temko,Sujata Biswas,Pierre Martinez,Marc J Williams,James O. Lindsay,Roger Feakins,Roser Vega,Stephen J. Hayes,Ian Tomlinson,Stuart McDonald,Morgan Moorghen,Andrew Silver,James E. East,Nicholas A. Wright,Lai Mun Wang,Manuel Rodriguez-Justo,Marnix Jansen,Ailsa Hart,Simon J. Leedham,Trevor A. Graham +25 more
TL;DR: This paper dissected the evolutionary history of colorectal cancer using multiregion sequencing and reconstructed the temporal sequence of events leading to CA-CRC using phylogenetic trees.
Journal ArticleDOI
Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy.
John M. Findlay,Francesc Castro-Giner,Seiko Makino,Emily Rayner,Christiana Kartsonaki,William Cross,Michal Kovac,Danny Ulahannan,Claire Palles,Richard S. Gillies,Thomas P. MacGregor,David N. Church,Nicholas D. Maynard,Francesca M. Buffa,Jean-Baptiste Cazier,Trevor A. Graham,Lai-Mun Wang,Ricky A. Sharma,Mark R. Middleton,Ian Tomlinson +19 more
TL;DR: In this article, the authors report whole-exome and deep sequencing of 30 paired oesophageal adenocarcinomas sampled before and after neo-adjuvant chemotherapy.
Journal ArticleDOI
New paradigms in clonal evolution: punctuated equilibrium in cancer.
TL;DR: It is proposed that a hybrid model, inspired by the evolutionary model of punctuated equilibrium, could better explain recent observations that have revealed both punctuated and neutral evolution phenomena that are poorly explained by the conventional graduated perspectives.
Journal ArticleDOI
Subclonal reconstruction of tumors by using machine learning and population genetics.
Giulio Caravagna,Timon Heide,Marc J Williams,Luis Zapata,Daniel Nichol,Ketevan Chkhaidze,William Cross,George D. Cresswell,Benjamin Werner,Ahmet Acar,Louis Chesler,Chris P. Barnes,Guido Sanguinetti,Guido Sanguinetti,Trevor A. Graham,Andrea Sottoriva +15 more
TL;DR: This work presents a novel approach for model-based tumor subclonal reconstruction (MOBSTER) that combines machine learning with theoretical population genetics and shows this method is more robust and accurate than current techniques in single sample, multi-region and longitudinal data.