Xuewu Liu

TL;DR: A multistage delivery system that can carry, release over time and deliver two types of nanoparticles into primary endothelial cells is shown, based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores.

TL;DR: Nanoscale confinement offers a new and general strategy for enhancing the contrast of gadolinium-based contrast agents by confining contrast agents inside the nanoporous structure of silicon particles.

TL;DR: It is shown that a tunable array of biodegradable nan oneedles fabricated by metal-assisted chemical etching of silicon can access the cytosol to co-deliver DNA and siRNA with an efficiency greater than 90%, and that in vivo the nanoneedles transfect the VEGF-165 gene, inducing sustained neovascularization and a localized sixfold increase in blood perfusion in a target region of the muscle.

TL;DR: The first in vivo therapeutic validation of a novel, multistage siRNA delivery system for sustained gene silencing with broad applicability to pathologies beyond ovarian neoplasms is provided.

TL;DR: A microfluidic device consisting of ciliated micropillars, forming a porous silicon nanowire-on-micropillar structure can preferentially trap exosome-like lipid vesicles, while simultaneously filtering out proteins and cell debris.