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Xuewu Liu
Researcher at Houston Methodist Hospital
Publications - 143
Citations - 8620
Xuewu Liu is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Drug delivery & Controlled release. The author has an hindex of 47, co-authored 139 publications receiving 7600 citations. Previous affiliations of Xuewu Liu include University of Texas Health Science Center at Houston & University of Texas at Austin.
Papers
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Journal ArticleDOI
Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications
Ennio Tasciotti,Xuewu Liu,Rohan Bhavane,Kevin D. Plant,Ashley D. Leonard,B. Katherine Price,Mark Ming-Cheng Cheng,Paolo Decuzzi,James M. Tour,Fredika M. Robertson,Mauro Ferrari,Mauro Ferrari,Mauro Ferrari +12 more
TL;DR: A multistage delivery system that can carry, release over time and deliver two types of nanoparticles into primary endothelial cells is shown, based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores.
Journal ArticleDOI
Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast.
Jeyarama S. Ananta,Biana Godin,Biana Godin,Richa Sethi,Loïck Moriggi,Xuewu Liu,Xuewu Liu,Rita E. Serda,Rita E. Serda,Ramkumar Krishnamurthy,Raja Muthupillai,Robert D. Bolskar,Lothar Helm,Mauro Ferrari,Lon J. Wilson,Paolo Decuzzi,Paolo Decuzzi +16 more
TL;DR: Nanoscale confinement offers a new and general strategy for enhancing the contrast of gadolinium-based contrast agents by confining contrast agents inside the nanoporous structure of silicon particles.
Journal ArticleDOI
Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization
Ciro Chiappini,E. De Rosa,Jonathan O. Martinez,Xuewu Liu,Joseph A. M. Steele,Molly M. Stevens,Ennio Tasciotti +6 more
TL;DR: It is shown that a tunable array of biodegradable nan oneedles fabricated by metal-assisted chemical etching of silicon can access the cytosol to co-deliver DNA and siRNA with an efficiency greater than 90%, and that in vivo the nanoneedles transfect the VEGF-165 gene, inducing sustained neovascularization and a localized sixfold increase in blood perfusion in a target region of the muscle.
Journal ArticleDOI
Sustained small interfering RNA delivery by mesoporous silicon particles
Takemi Tanaka,Lingegowda S. Mangala,Pablo E. Vivas-Mejia,René Nieves-Alicea,Aman P. Mann,Edna M. Mora,Edna M. Mora,Hee Dong Han,Mian M.K. Shahzad,Mian M.K. Shahzad,Xuewu Liu,Xuewu Liu,Rohan Bhavane,Jianhua Gu,Jean R. Fakhoury,Jean R. Fakhoury,Ciro Chiappini,Chunhua Lu,Koji Matsuo,Biana Godin,Rebecca L. Stone,Alpa M. Nick,Gabriel Lopez-Berestein,Anil K. Sood,Mauro Ferrari +24 more
TL;DR: The first in vivo therapeutic validation of a novel, multistage siRNA delivery system for sustained gene silencing with broad applicability to pathologies beyond ovarian neoplasms is provided.
Journal ArticleDOI
Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles
Wang Zongxing,Hung-Jen Wu,Daniel Fine,Jeffrey Schmulen,Ye Tony Hu,Biana Godin,John X. J. Zhang,Xuewu Liu +7 more
TL;DR: A microfluidic device consisting of ciliated micropillars, forming a porous silicon nanowire-on-micropillar structure can preferentially trap exosome-like lipid vesicles, while simultaneously filtering out proteins and cell debris.