Y
Yasuo Terauchi
Researcher at Yokohama City University
Publications - 413
Citations - 31656
Yasuo Terauchi is an academic researcher from Yokohama City University. The author has contributed to research in topics: Diabetes mellitus & Type 2 diabetes. The author has an hindex of 67, co-authored 382 publications receiving 29461 citations. Previous affiliations of Yasuo Terauchi include Texas A&M University & University of Tokyo.
Papers
More filters
Journal ArticleDOI
Pancreatic β-Cell-specific Targeted Disruption of Glucokinase Gene DIABETES MELLITUS DUE TO DEFECTIVE INSULIN SECRETION TO GLUCOSE
Yasuo Terauchi,Hiroshi Sakura,Kazuki Yasuda,Keiji Iwamoto,Noriko Takahashi,Kouichi Ito,Haruo Kasai,Hiroshi Suzuki,Otoya Ueda,Nobuo Kamada,Kou-ichi Jishage,Kajuro Komeda,Mitsuhiko Noda,Yasunori Kanazawa,Shigeki Taniguchi,Ichitomo Miwa,Yasuo Akanuma,Tatsuhiko Kodama,Yoshio Yazaki,Takashi Kadowaki +19 more
TL;DR: GK-deficient mice serve as an animal model of the insulin-secretory defect in human non-insulin-dependent diabetes mellitus and provide the first direct proof that GK serves as a glucose sensor molecule for insulin secretion and plays a pivotal role in glucose homeostasis.
Journal ArticleDOI
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.
Naoto Kubota,Tetsuya Kubota,Tetsuya Kubota,Shinsuke Itoh,Hiroki Kumagai,Hideki Kozono,Iseki Takamoto,Tomoka Mineyama,Hitomi Ogata,Kumpei Tokuyama,Mitsuru Ohsugi,Takayoshi Sasako,Masao Moroi,Kaoru Sugi,Shigeru Kakuta,Yoichiro Iwakura,Tetsuo Noda,Shin Ohnishi,Ryozo Nagai,Kazuyuki Tobe,Yasuo Terauchi,Kohjiro Ueki,Takashi Kadowaki +22 more
TL;DR: It is shown that hepatic Irs1 and Irs2 function in a distinct manner in the regulation of glucose homeostasis and the concept of the existence of a dynamic relay in hepatic insulin signaling during fasting and feeding is proposed.
Journal ArticleDOI
Role of Altered Renal Lipid Metabolism in the Development of Renal Injury Induced by a High-Fat Diet
Shinji Kume,Takashi Uzu,Shin-ichi Araki,Toshiro Sugimoto,Keiji Isshiki,Masami Chin-Kanasaki,Masayoshi Sakaguchi,Naoto Kubota,Yasuo Terauchi,Takashi Kadowaki,Masakazu Haneda,Atsunori Kashiwagi,Daisuke Koya +12 more
TL;DR: It is suggested that renal lipid metabolism could serve as a new therapeutic target to prevent chronic kidney disease in patients with metabolic syndrome by leading to an altered balance between renal lipogenesis and lipolysis, subsequent renal accumulation of lipid, and renal injury.
Journal ArticleDOI
Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial
Kohjiro Ueki,Takayoshi Sasako,Yukiko Okazaki,Masayuki Kato,Sumie Okahata,Hisayuki Katsuyama,Mikiko Haraguchi,Ai Morita,Ken Ohashi,Kazuo Hara,Atsushi Morise,Kazuo Izumi,Naoki Ishizuka,Yasuo Ohashi,Mitsuhiko Noda,Takashi Kadowaki,Masakazu Haneda,Yasunori Iwashima,Toshihiro Suda,Naoki Tamasawa,Makoto Daimon,Jo Satoh,Noriko Takebe,Yasushi Ishigaki,Tsuyoshi Watanabe,Hiroaki Satoh,Kikuo Kasai,Yoshimasa Aso,Shun Ishibashi,Shigehiro Katayama,San e. Ishikawa,Masafumi Kakei,Kazuyuki Namai,Naotake Hashimoto,Yoshifumi Suzuki,Shunichiro Onishi,Koutaro Yokote,Masafumi Matsuda,Masahiro Masuzawa,Yoichi Hayashi,Satoshi Saito,Norikazu Ogihara,Hisamitsu Ishihara,Naoko Tajima,Kazunori Utsunomiya,Akira Shimada,Hiroshi Itoh,Ryuzo Kawamori,Hirotaka Watada,Michio Hayashi,Yasumichi Mori,Teruo Shiba,Akihiro Isogawa,Hiroshi Sakura,Masato Odawara,Kazuyuki Tobe,Kazuhisa Tsukamoto,Toshimasa Yamauchi,Tamio Teramoto,Yukio Hirata,Isao Uchimura,Yoshihiro Ogawa,Gen Yoshino,Takahisa Hirose,Hiroshi Kajio,Yoshihito Atsumi,Yoichi Oikawa,Atsushi Araki,Akio Ueki,Atsushi Ohno,Masafumi Kitaoka,Yoshikuni Fujita,Tatsumi Moriya,Taiki Tojo,Masayoshi Shichiri,Daisuke Suzuki,Masao Toyoda,Kumiko Hamano,Rieko Komi,Yasuo Terauchi,Nobuaki Kuzuya,Masayo Yamada,Toshinari Takamura,Mitsuo Imura,Hiroshi Tanaka,Masayuki Hayashi,Yasuhisa Kato,Mitsuyasu Itoh,Atsushi Suzuki,Mikihiro Nakayama,Takahisa Sano,Eitaro Nakashima,Yasuhiro Sumida,Yutaka Yano,Tsuyoshi Tanaka,Kazuya Murata,Atsunori Kashiwagi,Hiroshi Maegawa,Shigeo Kono,Nobuya Inagaki,Keisuke Kosugi,Tetsuyuki Yasuda,Yasunao Yoshimasa,Ichiro Kishimoto,Toshihiko Sato,Masayuki Hosoi,Tomoyuki Yamasaki,Munehide Matsuhisa,Iichiro Shimomura,Ataru Taniguchi,Akira Kuroe,Takeshi Kurose,Takeshi Ohara,Kazuhiko Sakaguchi,Mitsuyoshi Namba,Kohei Kaku,Masazumi Fujiwara,Ikki Shimizu,Keizo Ono,Osamu Ebisui,Yukio Tanizawa,Yosuke Okada,Shoichi Natori,Takehiko Kodera,Naoichi Sato,Makoto Ide,Kentaro Yamada,Fumio Umeda,Tomoaki Eto,Kazuo Mimura,Shinsuke Hiramatsu,Tomoaki Inoue,Ryoko Takei,Atsushi Ogo,Katsumi Eguchi,Eiji Kawasaki,Yuji Koide,Eiichi Araki,Hideaki Jinnouchi,Hiroaki Yamamoto,Mitsutaka Motoyoshi,Toru Hiyoshi,Yasushi Tanaka,Tadahisa Momoki,Koichiro Sato,Akihiko Yoneyama,Kenichi Ito,Hiroshi Sobajima,Hiroshi Ikegami,Masaki Ikeda,Hiroki Ikeda,Kenji Takahashi,Hirofumi Makino,Yasuo Ueda,Masamitsu Nakazato +154 more
TL;DR: This multicentre, open-label, randomised, parallel-group trial, undertaken at 81 clinical sites in Japan, randomly assigned patients with type 2 diabetes with hypertension, dyslipidaemia, or both to receive conventional therapy or intensive therapy for glucose, blood pressure, and lipid control.
Journal ArticleDOI
Molecular mechanism of insulin resistance and obesity.
TL;DR: It is confirmed that replenishment of adiponectin represents a novel treatment strategy for insulin resistance and Type II diabetes using animal models and PPARγ is proved to be a thrifty gene mediating Type IIabetes.